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Primary Antibodies

GeneTex Antibodies
GeneTex primary antibodies have been tested through the use of various analytic strategies to ensure persistent quality and confirm antibody specificity. Based on the guidelines described by the International Working Group on Antibody Validation (IWGAV), GeneTex has been employing multiple approaches to certify antibody performance in our quality assurance process.
 

 

See GeneTex's Validation Methods

GeneTex understands the absolute necessity for reliable antibodies to achieve accurate and reproducible experimental results. To optimize the performance of our reagents, we employ various analytic validation strategies to ensure both consistent quality and specificity. These modalities are in line with guidelines described by the International Working Group on Antibody Validation (IWGAV) and have become fundamental components of our quality assurance process:

Five Pillars of Antibody Validation
Literature
Cardiovascular Research

Pamphlet - Cardiovascular Research

Download the latest version of GeneTex's cardiovascular research pamphlet.
Articles

Five Pillars of Antibody Validation

GeneTex employs various analytic validation strategies to ensure both consistent quality and specificity.
Newsletter
GeneTex Introduces Recombinant Monoclonal Iba1 Antibody

GeneTex Introduces Recombinant Monoclonal Iba1 Antibody

Newsletter
GeneTex Launches Novel Recombinant RAS (G12D Mutant) Antibody [HL10]

GeneTex Launches Novel Recombinant RAS (G12D Mutant) Antibody [HL10]

Newsletter

Leaky blood-brain barrier triggers neural dysfunction that is reversible

Leaky blood-brain barrier triggers neural dysfunction that is reversible
Literature
Cited Antibodies

Flyer - Cited Antibodies

Download the latest version of GeneTex's cited antibodies flyer.
Literature
Pyroptosis_and_Inflammation

Flyer-Pyroptosis_and_Inflammation

Literature
Obesity & Diabetes

Flyer - Obesity & Diabetes

Download the latest version of GeneTex's Obesity & Diabetes flyer.
Newsletter

A Cancer Immunotherapy Holy Grail?

A Cancer Immunotherapy Holy Grail?
Newsletter

MLLT3/AF9 is Pivotal for Human HSC Self-renewal and Engraftment

MLLT3/AF9 is Pivotal for Human HSC Self-renewal and Engraftment
Literature

Pamphlet - Antibodies for Hypoxia Research

Download the latest version of GeneTex's Antibodies for Hypoxia Research pamphlet.
Literature
Circadian Rhythm

Flyer - Circadian Rhythm

Download the latest version of GeneTex's Circadian Rhythm flyer.
Newsletter
Independent Knockout Validation of C9ORF72 Antibodies

Independent Knockout Validation of C9ORF72 Antibodies

Independent Knockout Validation of C9ORF72 Antibodies for the research of Amyotrophic lateral sclerosis.
Newsletter
Is ApoE the piece to complete the puzzle of Alzheimer’s disease?

Is ApoE the piece to complete the puzzle of Alzheimer’s disease?

ApoE was identified as a major checkpoint inhibitor of the classical complement cascade, and involved in a possible unifying mechanism underlying Alzheimer’s disease, atherosclerosis, and potentially other inflammatory diseases.
Literature
Neurotransmission

Flyer - Neurotransmission

Download the latest version of GeneTex's Neurotransmission flyer.
Newsletter
A Well-Cited Nrf2 Antibody for Cellular Redox Research

A Well-Cited Nrf2 Antibody for Cellular Redox Research

A quality Nrf2 antibody with multiple species reactivity for cellular redox research
Newsletter

Neurodegeneration: A "Vicious Cycle" Involving Mitochondria, Glia, and Neuronal Death

A "Vicious Cycle" Involving Mitochondria, Glia, and Neuronal Death
Newsletter

SETD3 Is Pivotal for Infection by Multiple Human Enteroviruses

In an exciting example of this concept, Diep et al. described the use of a genome-scale CRISPR screen to show that the protein histidine methyltransferase SETD3 is crucial for the replication of multiple human enteroviruses.
Newsletter

Soluble TREM2 is associated with clinical progression of Alzheimer’s disease.

A recent study by Ewers et al. reported that increased soluble TREM2 measured in cerebrospinal fluid was associated with lower rates of cognitive and clinical decline and progression in people with AD.
Newsletter
HBV

Adoptive T cell therapy shows potential to eliminate hepatitis B virus (HBV) infection.

Is a cure for chronic hepatitis B on the horizon? Adoptive T cell therapy shows potential to eliminate hepatitis B virus (HBV) infection.
Newsletter

Dogs Provide Great Help to Human Cancer Research

A large canine clinical trial was recently launched with the goal of developing a new cancer vaccine strategy that prevents tumor cells from developing into cancerous growths.
Newsletter
Online Biology Research Tools

Online Biology Research Tools

These tools include websites that perform sequence database interrogation, sequence analysis and alignment, and gene expression analysis.
Newsletter
exosome PD-L1

Improving cancer immunotherapy efficacy may depend on targeting exosomes

Improving cancer immunotherapy efficacy may depend on targeting exosomes bearing the immune checkpoint protein PD-L1
Literature
Recombinant Active Proteins

Pamphlet - Recombinant Active Proteins

Download the latest version of GeneTex's Recombinant Active Proteins Pamphlet.
Pathways

Autophagy Pathway

Autophagy is the process of self-cannibalization of cellular proteins or organelles through lysosomal degradation.
Pathways

Bcl-2 Pathway

B-cell lymphoma-2 (Bcl-2)-family proteins play an important role in regulating the induction of apoptosis.
Pathways

Notch Pathway

The Notch signaling pathway is an important evolutionarily conserved pathway that plays a vital role in the regulation of asymmetric cell division, cell fate specification, proliferation and apoptosis during development.
Literature
Cardiovascular Research

Pamphlet - Cardiovascular Research

Download the latest version of GeneTex's cardiovascular research pamphlet.
Literature
Cited Antibodies

Flyer - Cited Antibodies

Download the latest version of GeneTex's cited antibodies flyer.
Literature
Pyroptosis_and_Inflammation

Flyer-Pyroptosis_and_Inflammation

Literature
Obesity & Diabetes

Flyer - Obesity & Diabetes

Download the latest version of GeneTex's Obesity & Diabetes flyer.
Literature

Pamphlet - Antibodies for Hypoxia Research

Download the latest version of GeneTex's Antibodies for Hypoxia Research pamphlet.
Literature
Circadian Rhythm

Flyer - Circadian Rhythm

Download the latest version of GeneTex's Circadian Rhythm flyer.
Literature
Neurotransmission

Flyer - Neurotransmission

Download the latest version of GeneTex's Neurotransmission flyer.
Literature
Recombinant Active Proteins

Pamphlet - Recombinant Active Proteins

Download the latest version of GeneTex's Recombinant Active Proteins Pamphlet.
Literature
World Class Validated Antibodies

Brochure - World Class Validated Antibodies

Download the latest version of GeneTex's World Class Validated Antibodies brochure.
Literature
VetSignal Antibodies

Flyer - VetSignal Antibodies

Download the latest version of GeneTex's VetSignal Antibodies flyer.
Literature
Cancer Signaling

Poster - Cancer Signaling

Download the latest version of GeneTex's cancer signaling poster
Literature
Biological Research

Poster - Biological Research

Download the latest version of GeneTex's biological research poster
Literature
Mitochondria

Flyer - Mitochondria

Download the latest version of GeneTex's Mitochondria flyer.
Literature

Flyer - Fluorescence Immunostaining

Download the latest version of GeneTex's fluorescence immunostaining flyer.
Literature

Flyer - Five Pillars Validation

Download the latest version of GeneTex's epitope five pillars validation flyer.
Literature

Flyer - Loading Controls

Download the latest version of GeneTex's loading controls flyer.
Literature

Pamphlet - Western Blot Troubleshooting

Download the latest version of GeneTex's pamphlet for western blot troubleshooting.
Literature

Flyer - Upgrade Your Western Blot Results

Download the latest version of GeneTex's flyer for upgrade your western blot results.
Literature

Flyer - IHC Troubleshooting Guide

Download the latest version of GeneTex's IHC troubleshooting guide flyer.
Literature

Poster - Zebrafish

Download the latest version of GeneTex's zebrafish poster.
Literature

Poster - Stem Cell

Download the latest version of GeneTex's stem cell poster.
Literature
Neural Markers

Poster - Neural Markers

Download the latest version of GeneTex's neural markers poster.
Literature

Poster - Immune Response

Download the latest version of GeneTex's immune response poster.
Literature

Flyer - Epitope Tags and Reporters

Download the latest version of GeneTex's epitope tags and reporters flyer.
Literature
Organelle Markers

Poster - Organelle Markers

Download the latest version of GeneTex's organelle markers poster
Literature

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature
Epithelial–Mesenchymal Transition

Poster - EMT

Download the latest version of GeneTex's EMT poster
Articles

Five Pillars of Antibody Validation

GeneTex employs various analytic validation strategies to ensure both consistent quality and specificity.
Articles
Exosome/Microvesicle Markers

Exosome/Microvesicle Markers

Selected antibodies for your exosome research…
Articles
beta Amyloid

beta Amyloid

GeneTex’s “beta-Amyloid (1-42) antibody – Conformation-Specific” can specifically detect amyloid plaques in the Alzheimer's Disease brain by IHC-P analysis. The superior specificity and sensitivity of this antibody were confirmed by dot blot, ELISA and side-by-side IHC-P comparison with competitor's.
Articles

Approach to Antibody Lot-to-Lot Variability

Lot-to-lot variability is a persistent quality control (QC) issue that contributes to inconsistent results in assays using antibodies.
Articles

Overexpression Antibodies

The validity of a target protein’s endogenous signal can be further substantiated through overexpression of that protein using a recombinant construct.
Articles

Orthogonal_Antibodies

Detecting predicted changes in the antibody-generated signal due to alteration of experimental biological conditions is a reliable approach to gauge antibody performance.
Articles

IP/MS-antibodies

Using mass spectrometry (MS) to identify the protein(s) bound by an antibody is a powerful method for the validation of antibody specificity and performance.
Articles

Knockdown Technology

RNA interference (RNAi) refers to a cellular mechanism of post-transcriptional gene regulation through the actions of non-coding microRNAs (miRNAs).
Articles

Background of CRISPR/Cas9 technology

The RNA-guided CRISPR/Cas9 system is a revolutionary genome editing tool derived from the bacterial Type II CRISPR adaptive immune system.
Articles

Comparable antibodies

Comparing the signals generated by two independent antibodies for the same protein target in different samples is a practical way to test antibody specificity.
Articles

Knockout/Knockdown Validation

GeneTex is conducting knockout/knockdown-based validation as a fundamental component of its antibody quality assurance process.
Articles

ResponsibleScientists.org

An Open Letter Regarding Climate Change From Concerned Members of the U.S. National Academy of Sciences
Protocols

Protocol - Western Blot

Download GeneTex's Western Blot Protocol.
Protocols

Protocol - ICC/IF

Download GeneTex's ICC/IF Protocol.
Protocols

Protocol - IHC (paraffin)

Download GeneTex's IHC (paraffin) Protocol.
Protocols

Protocol - IHC (frozen)

Download GeneTex's IHC (frozen) Protocol.
Protocols

Protocol - IHC (whole-mount)

Download GeneTex's IHC (whole-mount) Protocol.
Protocols

Protocol - Immunoprecipitation

Download GeneTex's Immunoprecipitation Protocol.
Protocols

Protocol - ELISA (sandwich)

Download GeneTex's ELISA (sandwich) Protocol.
Protocols

Protocol - ELISA (indirect)

Download GeneTex's ELISA (indirect) Protocol.
Protocols

Protocol - Flow Cytometry

Download GeneTex's Flow Cytometry Protocol.
Protocols

Protocol - Dot Blot

Download GeneTex's Dot Blot Protocol.
Protocols

Protocol - Blocking Peptide Competition

Download GeneTex's Blocking Peptide Competition Protocol.
Newsletter
GeneTex Introduces Recombinant Monoclonal Iba1 Antibody

GeneTex Introduces Recombinant Monoclonal Iba1 Antibody

Newsletter
GeneTex Launches Novel Recombinant RAS (G12D Mutant) Antibody [HL10]

GeneTex Launches Novel Recombinant RAS (G12D Mutant) Antibody [HL10]

Newsletter

Leaky blood-brain barrier triggers neural dysfunction that is reversible

Leaky blood-brain barrier triggers neural dysfunction that is reversible
Newsletter

A Cancer Immunotherapy Holy Grail?

A Cancer Immunotherapy Holy Grail?
Newsletter

MLLT3/AF9 is Pivotal for Human HSC Self-renewal and Engraftment

MLLT3/AF9 is Pivotal for Human HSC Self-renewal and Engraftment
Newsletter
Independent Knockout Validation of C9ORF72 Antibodies

Independent Knockout Validation of C9ORF72 Antibodies

Independent Knockout Validation of C9ORF72 Antibodies for the research of Amyotrophic lateral sclerosis.
Newsletter
Is ApoE the piece to complete the puzzle of Alzheimer’s disease?

Is ApoE the piece to complete the puzzle of Alzheimer’s disease?

ApoE was identified as a major checkpoint inhibitor of the classical complement cascade, and involved in a possible unifying mechanism underlying Alzheimer’s disease, atherosclerosis, and potentially other inflammatory diseases.
Newsletter
A Well-Cited Nrf2 Antibody for Cellular Redox Research

A Well-Cited Nrf2 Antibody for Cellular Redox Research

A quality Nrf2 antibody with multiple species reactivity for cellular redox research
Newsletter

Neurodegeneration: A "Vicious Cycle" Involving Mitochondria, Glia, and Neuronal Death

A "Vicious Cycle" Involving Mitochondria, Glia, and Neuronal Death
Newsletter

SETD3 Is Pivotal for Infection by Multiple Human Enteroviruses

In an exciting example of this concept, Diep et al. described the use of a genome-scale CRISPR screen to show that the protein histidine methyltransferase SETD3 is crucial for the replication of multiple human enteroviruses.
Newsletter

Soluble TREM2 is associated with clinical progression of Alzheimer’s disease.

A recent study by Ewers et al. reported that increased soluble TREM2 measured in cerebrospinal fluid was associated with lower rates of cognitive and clinical decline and progression in people with AD.
Newsletter
HBV

Adoptive T cell therapy shows potential to eliminate hepatitis B virus (HBV) infection.

Is a cure for chronic hepatitis B on the horizon? Adoptive T cell therapy shows potential to eliminate hepatitis B virus (HBV) infection.
Newsletter

Dogs Provide Great Help to Human Cancer Research

A large canine clinical trial was recently launched with the goal of developing a new cancer vaccine strategy that prevents tumor cells from developing into cancerous growths.
Newsletter
Online Biology Research Tools

Online Biology Research Tools

These tools include websites that perform sequence database interrogation, sequence analysis and alignment, and gene expression analysis.
Newsletter
exosome PD-L1

Improving cancer immunotherapy efficacy may depend on targeting exosomes

Improving cancer immunotherapy efficacy may depend on targeting exosomes bearing the immune checkpoint protein PD-L1