Preservative: 0.05% Sodium Azide; Constituents: 1% BSA, PBS. pH 7.4
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Synthetic peptide: TASLDPDDFDPEPSDPLGSP, corresponding to amino acids 285-304 of extracellular domain of Rat ASIC3.
Immunogen affinity purified
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Acid Sensing Ion Channel Subunit 3 , Accn3 , Asic3
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, containing many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and is thought to play an important role in detecting lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium. Three transcript variants are generated following alternative splicing of this gene each encoding distinct isoforms.