APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
1/500 - 1/2000 |
1/200 - 1/1000 |
1/200 - 1/1000 |
1/200 - 1/400 |
1/10000 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
Ascites
Preservative
0.03% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Antigen Species
Human
Immunogen
Purified recombinant fragment of human ATXN1 expressed in E. Coli.
Purification
Unpurified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
ataxin 1 , ATX1 , D6S504E , SCA1
Cellular Localization
Cytoplasm,Nucleus
Background
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This loc
Database
Research Area
DATA IMAGES
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GTX80399 IHC-P Image
IHC-P analysis of ovarian cancer tissue (left) and lung cancer tissue (right) using GTX80399 Ataxin 1 antibody [2F5].
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GTX80399 ICC/IF Image
ICC/IF analysis of NTERA-2 cells using GTX80399 Ataxin 1 antibody [2F5]. Green : Ataxin 1 Blue: DRAQ5 fluorescent DNA dye Red: Actin filaments
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GTX80399 WB Image
WB analysis of HEK293 (1) and ATXN1(AA: 645-815)-hIgGFc transfected HEK293 (2) cell lysate using GTX80399 Ataxin 1 antibody [2F5].
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GTX80399 FACS Image
FACS analysis of Jurkat cells using GTX80399 Ataxin 1 antibody [2F5]. Green : Ataxin 1 Purple : negative control
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REFERENCE
There are currently no references for Ataxin 1 antibody [2F5] (GTX80399). Be the first to share your publications with this product.
REVIEW
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