GeneTex
United States (US)

BAFF Receptor recombinant protein

Cat No. GTX65456

Application ELISA, Functional Assay, Apuri, Blocking
Reactivity Human
Species Human
APPLICATION

Application Note

Protein's bioactivity determined by its ability to block BAFF induced mouse splenocyte survival. The expected ED50 for this effect is typically 1-5 ug/ml in the presence of 1 ug/ml human soluble BAFF.

Calculated MW

7.7 kDa. ( Note )
PROPERTIES

Form

Lyophilized powder

Buffer

20 mM phosphate buffer, pH 8.0, and 500 mM NaCl.

Storage

Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers or stored at 4ºC for 1 week or –20ºC for future use.

Antigen Species

Human

Expression System

E. coli

Purification


Purity was assessed by SDS-PAGE (≥95%) and by HPLC (≥95%).

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

human BAFF Receptor, h-BAFF Receptor, recombinant human BAFF Receptor, rhBAFF Receptor, hBAFF Receptor, rh-BAFF Receptor, recombinant BAFF Receptor, TR13C, h BAFF Receptor, rh BAFF Receptor

Background

BAFF Receptor (BAFFR), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFFR is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B). BAFFR/BAFF signaling plays a critical role in B cell survival and maturation. Recombinant human BAFFR is a 76 amino acid polypeptide (7.7 kDa) corresponding to the extraCellular portion of the full BAFFR protein.

Research Area

Package List Price ($)
$ 249