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Bcl-2 antibody [N1N2], N-term

Comparison Orthogonal Overexpression
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Anti-Bcl-2 antibody [N1N2], N-term used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX100064
Anti-Bcl-2 antibody [N1N2], N-term used in IHC (Paraffin sections) (IHC-P). GTX100064
Anti-Bcl-2 antibody [N1N2], N-term used in IHC (Paraffin sections) (IHC-P). GTX100064
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Anti-Bcl-2 antibody [N1N2], N-term used in IHC (Paraffin sections) (IHC-P). GTX100064
Anti-Bcl-2 antibody [N1N2], N-term used in IHC (Paraffin sections) (IHC-P). GTX100064
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064

Cat. No. GTX100064

Reference 117
19

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P

Reactivity

 Human, Mouse, Rat, Zebrafish, Cat, Dog
Package
100 μl ($399),
25 μl ($169)
See all Bcl-2 products
PRODUCT

Summary

BCL-2 antibody recognizes BCL-2 protein. BCL-2 (26 kDa) regulates mitochondrial dynamics, is involved in the regulation of mitochondrial fusion and fission, and is associated with apoptosis. Abnormal expression of BCL-2 protein is linked to various cancers, autoimmunity, and psychiatric disorders. This BCL-2 antibody is a widely published rabbit polyclonal validated for multiple applications.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
ICC/IF 1:100-1:1000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

26 kDa. ( Note )

Positive Control

BCL2-transfected 293T

Predict Reactivity

Bovine(>80% identity)

PROPERTIES

Form

Liquid

Buffer

1XPBS (pH7), 1% BSA, 20% Glycerol

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Bcl-2. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_2036326

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

BCL2 apoptosis regulator , Bcl-2 , PPP1R50

Cellular Localization

Mitochondrion outer membrane , Nucleus membrane , Endoplasmic reticulum membrane

Background

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064

GTX100064 WB Image

Comparison

Various whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Bcl-2 antibody [N1N2], N-term (GTX100064) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064

GTX100064 WB Image

Overexpression

Non-transfected (–) and transfected (+) 293T whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Bcl-2 antibody [N1N2], N-term (GTX100064) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Bcl-2 antibody [N1N2], N-term used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX100064

GTX100064 ICC/IF Image

Bcl-2 antibody [N1N2], N-term detects Bcl-2 protein at cytoplasm and nucleus by immunofluorescent analysis.
Sample: THP-1 cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: Bcl-2 stained by Bcl-2 antibody [N1N2], N-term (GTX100064) diluted at 1:500.
Blue: Fluoroshield with DAPI (GTX30920).

Anti-Bcl-2 antibody [N1N2], N-term used in IHC (Paraffin sections) (IHC-P). GTX100064

GTX100064 IHC-P Image

Immunohistochemical analysis of paraffin-embedded human breast cancer, using Bcl-2(GTX100064) antibody at 1:250 dilution.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-Bcl-2 antibody [N1N2], N-term used in IHC (Paraffin sections) (IHC-P). GTX100064

GTX100064 IHC-P Image

Bcl-2 antibody [N1N2], N-term detects Bcl-2 protein at cytoplasm in human squamous metaplasia of cervix by immunohistochemical analysis.
Sample: Paraffin-embedded human cervix.
Bcl-2 antibody [N1N2], N-term (GTX100064) diluted at 1:500.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064

GTX100064 WB Image

Rat tissue extract (50 μg) was separated by 12% SDS-PAGE, and the membrane was blotted with Bcl-2 antibody [N1N2], N-term (GTX100064) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.

Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064

GTX100064 WB Image

Whole cell extract (30 μg) was separated by 12% SDS-PAGE, and the membrane was blotted with Bcl-2 antibody [N1N2], N-term (GTX100064) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064

GTX100064 WB Image

Mouse tissue extract (50 μg) was separated by 12% SDS-PAGE, and the membrane was blotted with Bcl-2 antibody [N1N2], N-term (GTX100064) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064

GTX100064 WB Image

Orthogonal

Various whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Bcl-2 antibody [N1N2], N-term (GTX100064) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody. Corresponding RNA expression data for the same cell lines are based on Human Protein Atlas program.

Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064

GTX100064 WB Image

PG-4 whole cell extract (30 μg) was separated by 12% SDS-PAGE, and the membrane was blotted with Bcl-2 antibody (GTX100064) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.

Anti-Bcl-2 antibody [N1N2], N-term used in IHC (Paraffin sections) (IHC-P). GTX100064

GTX100064 IHC-P Image

Bcl-2 antibody detects Bcl-2 protein at cytoplasm and nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded dog mammary gland.
Bcl-2 stained by Bcl-2 antibody (GTX100064) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-Bcl-2 antibody [N1N2], N-term used in IHC (Paraffin sections) (IHC-P). GTX100064

GTX100064 IHC-P Image

Bcl-2 antibody detects Bcl-2 protein at cytoplasm and nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded dog skin.
Bcl-2 stained by Bcl-2 antibody (GTX100064) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064

GTX100064 WB Image

Whole cell extract (30 μg) was separated by 12% SDS-PAGE, and the membrane was blotted with Bcl-2 antibody (GTX100064) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.

REFERENCE

Application Reference

Shichao Li et al. Mol Neurobiol 2022; 59 (7) : 3996-4014 LncRNA BIRF Promotes Brain Ischemic Tolerance Induced By Cerebral Ischemic Preconditioning Through Upregulating GLT-1 via Sponging miR-330-5p.
Application : WB
Reactivity : Rat
Meng-Hui Zhang et al. Bioengineered 2022; 13 (4) : 10047-10060 Cleavage stimulation factor 2 promotes malignant progression of liver hepatocellular carcinoma by activating phosphatidylinositol 3'-kinase/protein kinase B/mammalian target of rapamycin pathway.
Application : WB
Chiang-Wen Lee et al. Molecules 2022; 27 (2) Naringenin Induces ROS-Mediated ER Stress, Autophagy, and Apoptosis in Human Osteosarcoma Cell Lines.
Application : WB
Reactivity : Human
Yang C et al. Oncol Lett 2022; 23 (4) : 139 NRBP1 negatively regulates SALL4 to reduce the invasion and migration, promote apoptosis and increase the sensitivity to chemotherapy drugs of breast cancer cells.
Application : WB
Reactivity : Human
Yuan F et al. CNS Neurosci Ther 2022; Hsa_circ_0072309 enhances autophagy and TMZ sensitivity in glioblastoma.
Application : WB
Reactivity : Human
Show More +
Submit a Reference

REVIEW

Bcl-2 antibody [N1N2], N-term Cat. No. GTX100064

Rating
( Average 4.9 based on 19 users reviews)
Application
Western Blot(WB)
( Average 4.9 based on 17 users reviews)
IHC (Paraffin sections)(IHC-P)
( Average 5 based on 2 users reviews)
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Date : Anonymous submitted on 10-Feb-2023
Score :
Application Tested : WB
Sample Species : Ms
Sample : Mouse brain tissue lysate
Amount used : 10ug
Blocking : 5% non-fat milk in TBST, 25°C, 0.5Hr
Primary Antibody : 1:500, 16°C, 25Hr
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Oxid Med Cell Longev in 2020.PMID: 32089770
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Front Pharmacol in 2017.PMID: 29326587
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Rat
Figure Note : The data was peer reviewed and published in the journal Evid Based Complement Alternat Med in 2013.PMID: 23573126
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Rat
Figure Note : The data was peer reviewed and published in the journal Stem Cell Res Ther in 2017.PMID: 28482861
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Biomolecules in 2020.PMID: 32635653
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Date : Anonymous submitted on 05-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Sample : U2OS cells
Amount used : 30 μg
Blocking : 5% non-fat dry milk in TBST, 25°C, 1Hr
Primary Antibody : 1:1000, 4°C, 12Hr
Figure Note : 0-30 μM cisplatin treatment for 24hr.
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Rat
Figure Note : The data was peer reviewed and published in the journal Oxid Med Cell Longev in 2019. PMID: 31210840
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Rat
Figure Note : The data was peer reviewed and published in the journal J Cell Mol Med in 2018. PMID: 29682889
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2015. PMID: 25849560
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2016. PMID: 26859149
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Evid Based Complement Alternat Med in 2012. PMID: 23091557
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Rat
Figure Note : The data was peer reviewed and published in the journal Apoptosis in 2020. PMID: 32100210
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Rat
Figure Note : The data was peer reviewed and published in the journal Apoptosis in 2020. PMID: 32100210
Anti-Bcl-2 antibody [N1N2], N-term used in IHC (Paraffin sections) (IHC-P). GTX100064
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : IHC-P
Sample Species : Rat
Figure Note : The data was peer reviewed and published in the journal Apoptosis in 2020. PMID: 32100210
Anti-Bcl-2 antibody [N1N2], N-term used in IHC (Paraffin sections) (IHC-P). GTX100064
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : IHC-P
Sample Species : Rat
Figure Note : The data was peer reviewed and published in the journal Apoptosis in 2020. PMID: 32100210
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Date : Anonymous submitted on 26-May-2018
Score :
Application Tested : WB
Sample Species : Hu
Sample : MG63 cells
Amount used : 30 μg
Blocking : 5% non-fat dry milk in TBST, 25°C, 1Hr
Primary Antibody : 1:1000, 4°C, 16Hr
Lane Description : Lane 1: Untreated MG63 whole cell lysate, Lane 2: Treated (IOX-1; 3uM) MG63 whole cell lysate, Lane 3: Treated (IOX-1; 10uM) MG63 whole cell lysateA:Untreated MG63 whole cell lysate
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Date : Anonymous submitted on 09-Jan-2015
Score :
Application Tested : WB
Sample Species : Ms
Sample : OKT3 cells
Amount used : 50μg
Blocking : 5% skim milk, 25°C, 1Hr
Primary Antibody : 1:1000, 25°C, 1Hr
Anti-Bcl-2 antibody [N1N2], N-term used in Western Blot (WB). GTX100064
Date : Anonymous submitted on 08-Dec-2014
Score :
Application Tested : WB
Sample Species : Hu
Sample : PA-1 cells
Amount used : 50μg
Blocking : 5% milk, 25°C, 0.5Hr
Primary Antibody : 1:2000, 4°C, 16Hr
Show More +
Submit a Review
Application Reference
Shichao Li et al. Mol Neurobiol 2022; 59 (7):3996-4014 LncRNA BIRF Promotes Brain Ischemic Tolerance Induced By Cerebral Ischemic Preconditioning Through Upregulating GLT-1 via Sponging miR-330-5p.
Application : WB
Reactivity : Rat
Meng-Hui Zhang et al. Bioengineered 2022; 13 (4):10047-10060 Cleavage stimulation factor 2 promotes malignant progression of liver hepatocellular carcinoma by activating phosphatidylinositol 3'-kinase/protein kinase B/mammalian target of rapamycin pathway.
Application : WB
Chiang-Wen Lee et al. Molecules 2022; 27 (2) Naringenin Induces ROS-Mediated ER Stress, Autophagy, and Apoptosis in Human Osteosarcoma Cell Lines.
Application : WB
Reactivity : Human
Yang C et al. Oncol Lett 2022; 23 (4):139 NRBP1 negatively regulates SALL4 to reduce the invasion and migration, promote apoptosis and increase the sensitivity to chemotherapy drugs of breast cancer cells.
Application : WB
Reactivity : Human
Yuan F et al. CNS Neurosci Ther 2022; Hsa_circ_0072309 enhances autophagy and TMZ sensitivity in glioblastoma.
Application : WB
Reactivity : Human
Lee CW et al. Molecules 2022; 27 (2):373 Naringenin Induces ROS-Mediated ER Stress, Autophagy, and Apoptosis in Human Osteosarcoma Cell Lines.
Application : WB
Reactivity : Human
Zhen Tian et al. Cell Cycle 2021; 20 (9):874-893 Promoting roles of KLF5 in myocardial infarction in mice involving microRNA-27a suppression and the following GFPT2/TGF-β/Smad2/3 axis activation.
Application : WB
Reactivity : Rat
Jianing Luo et al. Neurosci Bull 2021; 37 (2):242-254 Antagonism of Protease-Activated Receptor 4 Protects Against Traumatic Brain Injury by Suppressing Neuroinflammation via Inhibition of Tab2/NF-κB Signaling.
Application : WB
Reactivity : Mouse
Yuan-Kun Tu et al. Curr Neurovasc Res 2021; 18 (4):395-408 Human Olfactory Ensheathing Cell-derived Extracellular Cesicles: miRNA Profile and Neuroprotective Effect.
Application : WB
Reactivity : Human
Yi-Chun Chao et al. Int J Mol Sci 2021; 22 (11) Melatonin Downregulates PD-L1 Expression and Modulates Tumor Immunity in KRAS-Mutant Non-Small Cell Lung Cancer.
Application : WB
Reactivity : Human, Mouse
Shiau-Mei Chen et al. Biomolecules 2021; 11 (10) Activation of Aldehyde Dehydrogenase 2 Ameliorates Glucolipotoxicity of Pancreatic Beta Cells.
Application : WB
Reactivity : Mouse
Hongzhi Hu et al. J Nanobiotechnology 2021; 19 (1):390 Mitochondria-targeted accumulation of oxygen-irrelevant free radicals for enhanced synergistic low-temperature photothermal and thermodynamic therapy.
Application : WB
Reactivity : Human
Shehatta NH et al. Biomed Pharmacother 2021; 146:112599 Baicalin; a promising chemopreventive agent, enhances the antitumor effect of 5-FU against breast cancer and inhibits tumor growth and angiogenesis in Ehrlich solid tumor.
Application : IHC-P
Reactivity : Mouse
Xu C et al. Oxid Med Cell Longev 2021; 2021:2502324 Chronic Intermittent Hypoxia Regulates CaMKII-Dependent MAPK Signaling to Promote the Initiation of Abdominal Aortic Aneurysm.
Application : WB
Reactivity : Mouse
Zuo Y et al. Oxid Med Cell Longev 2021; 2021:9961628 Ferritinophagy-Mediated Ferroptosis Involved in Paraquat-Induced Neurotoxicity of Dopaminergic Neurons: Implication for Neurotoxicity in PD.
Application : WB
Tang J et al. Ecotoxicol Environ Saf 2021; 222:112531 Arsenic trioxide induces expression of BCL-2 expression via NF-κB and p38 MAPK signaling pathways in BEAS-2B cells during apoptosis.
Application : WB
Reactivity : Human
Du D. et al. Journal of Functional Foods 2021; 84:104584 Dietary supplementation of camel whey protein attenuates heat stress-induced liver injury by inhibiting NLRP3 inflammasome activation through the HMGB1/RAGE signalling pathway.
Application : IHC-P
Lam HYP et al. PLoS Negl Trop Dis 2021; 15 (6):e0009554 Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.
Application : WB
Reactivity : Mouse
Zhang J et al. Mediators Inflamm 2021; 2021:6611085 Anti-Interleukin-16-Neutralizing Antibody Attenuates Cardiac Inflammation and Protects against Cardiac Injury in Doxorubicin-Treated Mice.
Application : WB
Reactivity : Mouse
Luo LF et al. Front Pharmacol 2021; 12:669782 Astragaloside IV Attenuates the Myocardial Injury Caused by Adriamycin by Inhibiting Autophagy.
Application : WB
Reactivity : Rat
Wu YH et al. PLoS Pathog 2021; 17 (3):e1008866 Aerobic glycolysis supports hepatitis B virus protein synthesis through interaction between viral surface antigen and pyruvate kinase isoform M2.
Application : WB
Reactivity : Human
Li Y et al. Transl Lung Cancer Res 2021; 10 (4):1841-1856 Let-7b-3p inhibits tumor growth and metastasis by targeting the BRF2-mediated MAPK/ERK pathway in human lung adenocarcinoma.
Application : WB
Reactivity : Human
Qi Y et al. Cancer Cell Int 2021; 21 (1):74 Cisplatin loaded multiwalled carbon nanotubes reverse drug resistance in NSCLC by inhibiting EMT.
Application : WB
Reactivity : Human
Huang SQ et al. World J Gastroenterol 2021; 27 (9):815-834 Abdominal paracentesis drainage attenuates intestinal inflammation in rats with severe acute pancreatitis by inhibiting the HMGB1-mediated TLR4 signaling pathway.
Application : WB
Reactivity : Rat
Jao TM et al. Cancer Lett 2021; 499:290-300 PCDH10 exerts tumor-suppressor functions through modulation of EGFR/AKT axis in colorectal cancer.
Application : WB
Reactivity : Human
Cui W et al. Cell Prolif 2021; 54 (2):e12964 20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study.
Application : WB
Reactivity : Mouse
Wang Y et al. Aging (Albany NY) 2020; 12 (20):20184-20197 Interleukin-6 knockout reverses macrophage differentiation imbalance and alleviates cardiac dysfunction in aging mice.
Wu X et al. Chin Neurosurg J 2020; 6:1 SIRT3 protects against early brain injury following subarachnoid hemorrhage via promoting mitochondrial fusion in an AMPK dependent manner.
Lam HYP et al. Biomolecules 2020; 10 (7) Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice.
Liu W et al. Oxid Med Cell Longev 2020; 2020:5167292 The Phenoxyphenol Compound 4-HPPP Selectively Induces Antiproliferation Effects and Apoptosis in Human Lung Cancer Cells through Aneupolyploidization and ATR DNA Repair Signaling.
Wang J et al. Mol Neurobiol 2020; (Epub) Estrogen Attenuates Traumatic Brain Injury by Inhibiting the Activation of Microglia and Astrocyte-Mediated Neuroinflammatory Responses.
Application : WB
Reactivity : Mouse
Wen Y et al. World J Gastroenterol 2020; 26 (1):35-54 Abdominal paracentesis drainage ameliorates myocardial injury in severe experimental pancreatitis rats through suppressing oxidative stress.
Wu X et al. Cell Prolif 2020; 53 (2):e12759 Recombinant adiponectin peptide promotes neuronal survival after intracerebral haemorrhage by suppressing mitochondrial and ATF4-CHOP apoptosis pathways in diabetic mice via Smad3 signalling inhibition.
Li M et al. Cancer Manag Res 2020; 12:9159-9171 Downregulation of circNRIP1 Suppresses the Paclitaxel Resistance of Ovarian Cancer via Regulating the miR-211-5p/HOXC8 Axis.
Application : WB
Reactivity : Human
Zeng M et al. Cancer Manag Res 2020; 12:8801-8811 The Anti-Apoptotic Role of EBV-LMP1 in Lymphoma Cells.
Application : WB
Reactivity : Human
Zaitone SA et al. Life Sci 2020; 262:118467 Retinoprotective effect of donepezil in diabetic mice involves mitigation of excitotoxicity and activation of PI3K/mTOR/BCl2 pathway.
Application : IHC-P
Reactivity : Mouse
Huang YY et al. BMC Vet Res 2020; 16 (1):193 Inhibiting autophagy potentiates the antitumor efficacy of Euphorbia royleana for canine mammary gland tumors.
Application : WB
Lin CT et al. Elife 2020; 9 3,6'-dithiopomalidomide reduces neural loss, inflammation, behavioral deficits in brain injury and microglial activation.
Application : IHC-P
Reactivity : Rat
Kuang Y et al. Mol Med Rep 2020; 22 (4):2783-2790 Protective effect of dimethyl fumarate on oxidative damage and signaling in cardiomyocytes.
Application : WB
Reactivity : Rat
Chang YC et al. Front Cell Dev Biol 2020; 8:485 Tamoxifen Rechallenge Decreases Metastatic Potential but Increases Cell Viability and Clonogenicity in a Tamoxifen-Mediated Cytotoxicity-Resistant Subline of Human Breast MCF7 Cancer Cells.
Application : WB
Reactivity : Human
Wu X et al. Neurosci Bull 2020; (Epub) Acrolein Aggravates Secondary Brain Injury After Intracerebral Hemorrhage Through Drp1-Mediated Mitochondrial Oxidative Damage in Mice.
Application : WB
Reactivity : Mouse
Chung YC et al. Eur J Clin Invest 2020;:e13255 Application of trastuzumab emtansine in HER-2-positive and KRAS/BRAF-mutated colon cancer cells.
Application : WB
Reactivity : Human
Chang JW et al. Cereb Cortex 2020; 30 (8):4597-4606 Ultrasound Stimulation Suppresses LPS-Induced Proinflammatory Responses by Regulating NF-κB and CREB Activation in Microglial Cells.
Application : WB
Reactivity : Rat
Luo C et al. Apoptosis 2020; Abdominal paracentesis drainage attenuates severe acute pancreatitis by enhancing cell apoptosis via PI3K/AKT signaling pathway.
Application : WB
Reactivity : Rat
Wang W et al. Hum Exp Toxicol 2020;:960327120901586 Neuroprotective effects of notoginsenoside R1 by upregulating Trx-1 on acrylamide-induced neurotoxicity in PC12.
Application : WB
Reactivity : Rat
Wangta Liu et al. Oxidative Medicine and Cellular Longevity 2020; 2020:Article ID 5167292 The Phenoxyphenol Compound 4-HPPP Selectively Induces Antiproliferation Effects and Apoptosis in Human Lung Cancer Cells through Aneupolyploidization and ATR DNA Repair Signaling.
Application : WB
Reactivity : Human
Kim SG et al. Korean J Physiol Pharmacol 2020; 24 (1):69-79 Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway.
Application : WB
Reactivity : Rat
Yang K et al. Oncol Rep 2020; (Epub) PI3K/mTORC1/2 inhibitor PQR309 inhibits proliferation and induces apoptosis in human glioblastoma cells.
Application : WB
Reactivity : Human
Jiao L et al. Cell Death Dis 2019; 10 (12):942 lncRNA-ZFAS1 induces mitochondria-mediated apoptosis by causing cytosolic Ca2+ overload in myocardial infarction mice model.
Lu CC et al. Int J Oncol 2019; 54 (4):1271-1281 Metformin triggers the intrinsic apoptotic response in human AGS gastric adenocarcinoma cells by activating AMPK and suppressing mTOR/AKT signaling.
Gautam A et al. Front Immunol 2019; 10:1160 Peritoneal Cells Mediate Immune Responses and Cross-Protection Against Influenza A Virus.
Yan L et al. Lab Invest 2019; Inhibition of microRNA-21-5p reduces keloid fibroblast autophagy and migration by targeting PTEN after electron beam irradiation.
Application : WB
Reactivity : Human
Ding Y et al. Toxicology 2019; 422:102-120 Study on the metabolism toxicity, susceptibility and mechanism of di-(2-ethylhexyl) phthalate on rat liver BRL cells with insulin resistance in vitro.
Application : WB
Reactivity : Rat
Kurniawan AL et al. Food Funct 2019; 10 (7):4113-4123 Alteration in iron efflux affects male sex hormone testosterone biosynthesis in a diet-induced obese rat model.
Application : WB
Reactivity : Rat
Wei GJ et al. AAPS J 2019; 21 (5):86 A Tangeretin Derivative Inhibits the Growth of Human Prostate Cancer LNCaP Cells by Epigenetically Restoring p21 Gene Expression and Inhibiting Cancer Stem-like Cell Proliferation.
Application : WB
Reactivity : Human
You BJ et al. Sci Rep 2019; 9 (1):3306 Fenofibrate induces human hepatoma Hep3B cells apoptosis and necroptosis through inhibition of thioesterase domain of fatty acid synthase.
Application : WB
Reactivity : Human
Saat N et al. Biotech Histochem 2019;:1-7 Effect of melatonin on torsion and reperfusion induced pathogenesis of rat uterus.
Application : IHC-P
Reactivity : Rat
Li H et al. J Cell Physiol 2019; (Epub) Mitochondrial proteomics reveals the mechanism of spermatogenic cells apoptosis induced by carbon ion radiation in zebrafish.
Application : WB
Reactivity : Zebrafish
Wen Y et al. Oxid Med Cell Longev 2019; 2019:4578175 NADPH Oxidase Hyperactivity Contributes to Cardiac Dysfunction and Apoptosis in Rats with Severe Experimental Pancreatitis through ROS-Mediated MAPK Signaling Pathway.
Application : WB
Reactivity : Rat
Dasgupta A et al. IUBMB Life 2019; (Epub) Astrakurkurone, a Sesquiterpenoid from Wild Edible Mushroom, Targets Liver Cancer Cells by Modulating Bcl-2 Family Proteins.
Application : WB
Reactivity : Human
Yuan F et al. Cancer Lett 2019; 446:1-14 TIPE3 is a regulator of cell apoptosis in glioblastoma.
Application : WB
Reactivity : Human
Batsaikhan B et al. Int J Mol Sci 2019; 20 (3) post-injury neuroprotective effects of the * analog 3,6'-dithio* on traumatic brain injury.
Application : IHC-P
Reactivity : Rat
Yu H et al. Microcirculation 2019;:e12537 Effect of mild hypothermia on cerebral microcirculation in a murine cardiopulmonary resuscitation model.
Application : WB
Reactivity : Rat
Abdel-Daim MM et al. Sci Total Environ 2019; 650 (Pt 2):2063-2073 Hepatorenal protective effects of taurine and N-acetylcysteine against fipronil-induced injuries: The antioxidant status and apoptotic markers expression in rats.
Application : IHC-P
Reactivity : Rat
Lee S et al. CNS Neurosci Ther 2018; 24 (10):930-939 Estrogen receptor-β of microglia underlies sexual differentiation of neuronal protection via ginsenosides in?mice?brain.
Lee CW et al. J Cell Physiol 2018; (Epub) Artocarpin induces cell apoptosis in human osteosarcoma cells through endoplasmic reticulum stress and reactive oxygen species.
Application : WB
Reactivity : Human
Si J et al. Toxicology 2018; (Epub) Effects of ionizing radiation and HLY78 on the zebrafish embryonic developmental toxicity.
Application : WB
Reactivity : Zebrafish
Wang TH et al. Int J Mol Sci 2018; 19 (9) Melatonin Inhibits the Progression of Hepatocellular Carcinoma through MicroRNA Let7i-3p Mediated RAF1 Reduction.
Application : WB
Reactivity : Human
Lee CF et al. Biomedicine (Taipei) 2018; 8 (3):15 benzyl isothiocyanate (bitc) triggers mitochondria-mediated apoptotic machinery in human *-resistant oral cancer car cells.
Application : WB
Reactivity : Human
Jianghe Cui et al. Int J Clin Exp Med 2018; 11 (8):8275-8281 MiR-365 promotes hepatoma cell apoptosis through regulating DJ-1-PTEN/PI3K/AKT signaling pathway.
Application : WB
Reactivity : Human
Ho Y et al. Food Chem Toxicol 2018; 120:346-355 Resveratrol inhibits human leiomyoma cell proliferation via crosstalk between integrin αvβ3 and IGF-1R.
Application : WB
Reactivity : Human
Jui-Cheng Tsai et al. Journal of Functional Foods 2018; 48:283-296 Extracts of Cerbera manghas L. effectively inhibit the viability of glioblastoma cell lines and their cancer stemloids in vitro and in mouse xenograft model.
Application : WB
Reactivity : Human
Pengfei Deng et al. International Journal of Science 2018; 5:5 Hsp90 inhibitor SNX-2112 inhibits cell growth by regulating Bcl-2 family proteins and cyclin proteins in MCF-7 cells.
Application : WB
Reactivity : Human
Ran S et al. Int Endod J 2018; (Epub) Enterococcus faecalis induces apoptosis and pyroptosis of human osteoblastic MG63 cells via the NLRP3 inflammasome.
Application : WB
Reactivity : Human
Xiao YF et al. J Cell Mol Med 2018; (Epub) FKBP12.6 protects heart from AngII-induced hypertrophy through inhibiting Ca2+ /calmodulin-mediated signalling pathways in-vivo and in-vitro.
Application : WB
Reactivity : Mouse
Dong T et al. Biomedicine & Pharmacotherapy 2018; 102:874-883 The protective roles of L-borneolum, D-borneolum and synthetic borneol in cerebral ischaemia via modulation of the neurovascular unit.
Application : IHC-P
Reactivity : Rat
Chen PY et al. Int J Mol Sci 2018; 19 (4) Response of Myeloid Leukemia Cells to Luteolin is Modulated by Differentially Expressed Pituitary Tumor-Transforming Gene 1 (PTTG1) Oncoprotein.
Application : WB
Reactivity : Human
Kim SH et al. Biomedicine & Pharmacotherapy 2018; 99:997-1008 Teroxirone suppresses growth and motility of human hepatocellular carcinoma cells.
Application : WB
Reactivity : Human
Chang HP et al. Int J Oncol 2018; (Epub) pterostilbene modulates the suppression of multidrug resistance protein-1 and triggers autophagic and apoptotic mechanisms in *-resistant human oral cancer car cells via akt signaling.
Application : WB
Reactivity : Human
Chung YC et al. Sci Rep 2018; 8 (1):3930 *-induced caveolin-1 expression promotes t-dm1 drug efficacy in breast cancer cells.
Application : WB
Reactivity : Human
Gunes-Bayir A et al. Mol Cell Biochem 2018; (Epub) Effects of carvacrol on human fibroblast (WS-1) and gastric adenocarcinoma (AGS) cells in vitro and on Wistar rats in vivo.
Application : IHC-P
Reactivity : Rat
Azmy MS et al. Mol Neurobiol 2018; (Epub) neuroprotective effects of * in rotenone-induced parkinson's disease in rats: insights into its anti-inflammatory, neurotrophic, and antiapoptotic effects.
Application : IHC-P
Reactivity : Rat
Lin SC et al. Oncol Rep 2018; 39 (2):703-710 Glycyrrhizic acid induces human MDA-MB-231 breast cancer cell death and autophagy via the ROS-mitochondrial pathway.
Application : WB
Yang JS et al. Oncol Rep 2018; 39 (1):383-391 ITR-284 modulates cell differentiation in human chronic myelogenous leukemia K562 cells.
Huang WT et al. Front Pharmacol 2017; 8:902 HDAC2 and HDAC5 Up-Regulations Modulate Survivin and miR-125a-5p Expressions and Promote Hormone Therapy Resistance in Estrogen Receptor Positive Breast Cancer Cells.
Wang JP et al. Oncol Lett 2017; 14 (3):3503-3509 Reactive oxygen species-driven mitochondrial injury induces apoptosis by teroxirone in human non-small cell lung cancer cells.
Li J et al. Stem Cell Res Ther 2017; 8 (1):107 therapeutic effect of urine-derived stem cells for */lipopolysaccharide-induced interstitial cystitis in a rat model.
Lee SO et al. J Ginseng Res 2017; (Epub) Korean red ginseng enhances pneumococcal Δpep27 vaccine efficacy by inhibiting reactive oxygen species production.
Application : WB
Reactivity : Mouse
Toraih EA et al. Tumour Biol 2017; 39 (11):1.01E+15 MicroRNA-target cross-talks: Key players in glioblastoma multiforme.
Application : IHC-P
Reactivity : Human
Lin GL et al. PLoS One 2017; 12 (10):e0185625 modulation of the mrna-binding protein hur as a novel reversal mechanism of *-triggered multidrug resistance in colorectal cancer cells.
Application : WB
Reactivity : Human
Wu JS et al. Mol Neurobiol 2017; (Epub) Clinacanthus nutans Mitigates Neuronal Apoptosis and Ischemic Brain Damage Through Augmenting the C/EBPβ-Driven PPAR-γ Transcription.
Application : WB
Reactivity : Mouse
Chen HY et al. Int J Mol Sci 2017; 18 (10) Isoliquiritigenin Induces Autophagy and Inhibits Ovarian Cancer Cell Growth.
Application : WB
Reactivity : Human
Tsui KH et al. Reproduction 2017; 154 (2):101-110 DHEA protects mitochondria against dual modes of apoptosis and necroptosis in human granulosa HO23 cells.
Application : WB
Reactivity : Human
Gao Z et al. Hindawi 2017; (Epub) Dab1 contributes to angiotensin II-induced apoptosis via p38 signaling pathway in podocytes.
Application : WB
Reactivity : Mouse
Eid W et al. J Cell Biochem 2017; (Epub) neferine enhances the antitumor effect of *-c in hela cells through the activation of p38-mapk pathway.
Application : WB
Reactivity : Human
Lee CC et al. PLoS One 2017; 12 (3):e0173890 the microrna-302b-inhibited *-like growth factor-binding protein 2 signaling pathway induces glioma cell apoptosis by targeting nuclear factor ia.
Application : WB
Reactivity : Human
Hsu SW et al. BMC Complement Altern Med 2017; 17 (1):29 Rhodiola crenulata extract counteracts the effect of hypobaric hypoxia in rat heart via redirection of the nitric oxide and arginase 1 pathway.
Application : WB
Reactivity : Rat
Liu Y et al. Technol Cancer Res Treat 2016; 15 (3):487-97 Effects of Oxymatrine on the Proliferation and Apoptosis of Human Hepatoma Carcinoma Cells.
Application : IHC-P
Reactivity : Mouse
Chen MF et al. BMC Cancer 2016; 16:532 Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells.
Application : WB
Reactivity : Human
Chen PH et al. Neuropharmacology 2016; 110 (Pt A):362-75 The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death.
Application : WB
Reactivity : Human
Chen HH et al. Sci Rep 2016; 6:27945 Urinary miR-16 transactivated by C/EBPβ reduces kidney function after ischemia/reperfusion-induced injury.
Application : WB
Reactivity : Human
Y Zhang et al. Journal of Materials Chemistry B 2016; (Epub) Surface modification with E-cadherin fusion protein for mesenchymal stem cell culture.
Application : WB
Reactivity : Human
Buchkremer S et al. JND 2016; 3 (2):169-181 Sil1-Mutant Mice Elucidate Chaperone Function in Neurological Disorders.
Application : IHC-P
Reactivity : Mouse
Fu X et al. PLoS One 2016; 11 (2):e0148819 High-Dose Fluoride Impairs the Properties of Human Embryonic Stem Cells via JNK Signaling.
Application : WB
Reactivity : Human
Huang CC et al. Oncotarget 2015; 6 (11):8698-708 Paxillin promotes colorectal tumor invasion and poor patient outcomes via ERK-mediated stabilization of Bcl-2 protein by phosphorylation at Serine 87.
Application : WB, IHC-P
Reactivity : Human
Lu JW et al. Med Oncol 2015; 32 (7):206 mk-2206 induces apoptosis of aml cells and enhances the cytotoxicity of *.
Application : WB
Reactivity : Human
Li CJ et al. Sci Rep 2015; (Epub) Synergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosis.
Application : WB
Reactivity : Human
Hsu WH et al. PLoS One 2015; 10 (4):e0121298 Evaluation of the medicinal herb Graptopetalum paraguayense as a treatment for liver cancer.
Application : WB
Reactivity : Human
Szu-Ting Lin et al. Cellular and Molecular Life Sciences 2015; 72 (12):2395-409 pgrmc1 contributes to *-induced chemoresistance in mes-sa uterine sarcoma.
Application : WB
Reactivity : Human
J. Abdi et al. The Journal of Nutritional Biochemistry 2014; Omega-3 fatty acids, EPA and DHA induce apoptosis and enhance drug sensitivity in multiple myeloma cells but not in normal peripheral mononuclear cells
Application : WB
Reactivity : Human
Pu YF et al. Int J Clin Exp Pathol 2014; 7 (4):1563-71 Generation of homologous cell pairs using the oral lymphatic system.
Application : WB
Reactivity : Human
Lee JG et al. Toxicol In Vitro 2014; 28 (4):562-570 Acrylamide-induced apoptosis in rat primary astrocytes and human astrocytoma cell lines.
Application : WB
Reactivity : Human, Rat
Abdi J et al. Blood Cancer J 2013; 3:e119 stimulation of toll-like receptor-1/2 combined with * increases cytotoxicity to human multiple myeloma cells.
Application : WB
Reactivity : Human
Wu DW et al. Oncogene 2013; phosphorylation of paxillin confers * resistance in non-small cell lung cancer via activating erk-mediated bcl-2 expression.
Application : WB, IHC-P
Reactivity : Human
Chen YW et al. Evid Based Complement Alternat Med 2013; 2013:364519 Cardioprotective Effects of Quercetin in Cardiomyocyte under Ischemia/Reperfusion Injury.
Application : WB
Reactivity : Rat
Li CJ et al. Evid Based Complement Alternat Med 2012; 2012:261971 Momordica charantia Extract Induces Apoptosis in Human Cancer Cells through Caspase- and Mitochondria-Dependent Pathways.
Application : WB
Reactivity : Human
Liu CH et al. J Ethnopharmacol 2011; 137 (1):503-11 Subamolide A, a component isolated from Cinnamomum subavenium, induces apoptosis mediated by mitochondria-dependent, p53 and ERK1/2 pathways in human urothelial carcinoma cell line NTUB1.
Application : WB
Reactivity : Human
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