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CD19 antibody [HIB19] (PE-Cy7)

Anti-CD19 antibody [HIB19] (PE-Cy7) used in Flow cytometry (FACS). GTX01455-10

Cat No. GTX01455-10

Reference 1684

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 HIB19

Isotype

 IgG1

Application

 FACS

Reactivity

 Human
Package
100 test ($239)
See all CD19 products
PRODUCT

Summary

The HIB19 antibody reacts with human CD19, a 95 kDa glycoprotein which acts as a co-receptor, along with CD21, CD81 and CD225, in support of the functional B cell receptor (BCR). This complex provides antigen-specific recognition and subsequent activation of B cells to proliferate and differentiate into antibody-secreting cells (plasma cells) or memory B cells, which are crucial for secondary antigen encounter. CD19 is a lineage-differentiation marker, as its expression is detectable at the earliest B cell stages, through development, and is finally lost upon transition to mature plasma cells.The HIB19 antibody is widely used as a phenotypic marker for CD19 expression on B cells, as well as on dendritic cell subsets.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
FACS 0.25 μg (5 μl) for 10⁵-10⁸ cells in 100 μl sample per test
Not tested in other applications.

Calculated MW

61 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM NaH₂PO₄ (pH7.2), 150mM NaCl, 0.1% Gelatin

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

0.05 mg/ml (Please refer to the vial label for the specific concentration.)

Purification

Purified by affinity chromatography
From tissue culture supernatant

Conjugation

Phycoerythrin-Cyanine7 (PE-Cy7)

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CD19 molecule , B4 , CD19 , CVID3

Cellular Localization

Membrane

Background

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-CD19 antibody [HIB19] (PE-Cy7) used in Flow cytometry (FACS). GTX01455-10

GTX01455-10 FACS Image

FACS analysis of human peripheral blood lymphocytes using GTX01455-10 CD19 antibody [HIB19] (PE-Cy7).
Solid lone : primary antibody
Dashed line : isotype control
antibody amount : 0.25 μg (5 μl)

REFERENCE

Clone Reference

Benjelloun F et al. Front Immunol 2020; 11:1655 Activation of Toll-Like Receptors Differentially Modulates Inflammation in the Human Reproductive Tract: Preliminary Findings.
Bourdely P et al. Immunity 2020; 53 (2):335-352.e8 Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells.
Salzer B et al. Nat Commun 2020; 11 (1):4166 Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function.
Imura Y et al. JCI Insight 2020; 5 (14) CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD.
Zhao NQ et al. PLoS One 2020; 15 (9):e0238347 Natural killer cell phenotype is altered in HIV-exposed seronegative women.
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Clone Reference
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