0.01M PBS pH7.4, 15 mM sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.)
rat α-CGRP peptide. The epitope recognized by the antibody resides within the C-terminal ten amino acids of rat α-CGRP.
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
CGRP-I, CGRPI, KC, P01258, 796, Cal1, CALCA, 24241, CT, CGRP1, CAL6, Calc, CALC1, CGRP, MGC126648, calcitonin, RATCAL6, 114130, CGRP I
Calcitonin gene-related peptide (CGRP), amylin (AMY), and adrenomedullin (ADM) are structurally related peptides of the same family. They are characterized by six to seven amino acid ring structure linked by a disulfide bridge and an amidated C-terminus. CGRP is a 37 amino acid peptide derived from the alternative splicing, which is tissue specific, of the calcitonin gene and may exist in two forms alpha and beta with similar biological functions. Calcitonin gene-related peptide is widely found in both the central and peripheral (sensory and motor neurons) nervous systems. Structural activity studies have found that following peripheral or intracerebroventricular injections of CGRP, several biological actions have been demonstrated that are mediated by the activation of the CGRP receptor subtypes designated CGRP1 and CGRP2. BIBN4096BS, a potent non-peptide antagonist, competitively antagonizes the effects of CGRP in the rat atrium with a potency of about 10-fold higher than that of CGRP (8-37). BIBN4096BS was much less potent at antagonizing the effects of CGRP, proposed to be mediated by the CGRP2 subtype. An orphan receptor originally described as the calcitonin-receptor- like receptor (CRLR) has been identified as a CGRP receptor. Co-expression with a single transmembrane receptor, termed receptor-activity-modifying protein 1 (RAMP1), is required for this receptor to behave as a CGRP1 receptor.