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CIITA antibody

Anti-CIITA antibody used in IHC (Paraffin sections) (IHC-P). GTX31419
Anti-CIITA antibody used in Western Blot (WB). GTX31419
Anti-CIITA antibody used in IHC (Paraffin sections) (IHC-P). GTX31419

Cat No. GTX31419

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P, ELISA
Reactivity Human, Mouse, Rat
Package
100 μg ($329)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1 μg/mL
IHC-P 10 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

124 kDa. ( Note )

Positive Control

Human Brain Tissue Slide(GTX22203) , Rat Brain Tissue Lysate(GTX27942)
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

CIITA antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CIITA.The immunogen is located within amino acids 120 - 170 of CIITA.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

class II major histocompatibility complex transactivator , C2TA , CIITAIV , MHC2TA , NLRA

Cellular Localization

Nucleus

Background

This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Database

Research Area

DATA IMAGES
Anti-CIITA antibody used in IHC (Paraffin sections) (IHC-P). GTX31419

GTX31419 IHC-P Image

IHC-P analysis of human brain tissue using GTX31419 CIITA antibody.
Working concentration : 10 μg/ml

Anti-CIITA antibody used in Western Blot (WB). GTX31419

GTX31419 WB Image

WB analysis of rat brain tissue lysate using GTX31419 CIITA antibody.
Working concentration : 1 μg/ml

Anti-CIITA antibody used in IHC (Paraffin sections) (IHC-P). GTX31419

GTX31419 IHC-P Image

IHC-P analysis of human brain tissue using GTX31419 CIITA antibody.
Working concentration : 20 μg/ml

REFERENCE
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