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CLCN7 antibody

Anti-CLCN7 antibody used in Western Blot (WB). GTX00807
Anti-CLCN7 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX00807

Cat No. GTX00807

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ICC/IF

Reactivity

Human
Package
100 μl ($329)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:1000
ICC/IF 1:100-1:500
Not tested in other applications.

Calculated MW

89 kDa. ( Note )

Predict Reactivity

Rabbit, Bovine(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS pH 7.4, 150mM NaCl, 0.02% sodium azide, 50% glycerol

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthesized peptide derived from human CLCN7, corresponding to a region within N-terminal amino acids.

Purification

Purified by antigen-affinity chromatography
From serum

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CLC7,CLCN7,OPTA2,OPTB4,PPP1R63,chloride voltagegated channel 7,chloride voltage-gated channel 7

Cellular Localization

Lysosome membrane

Background

The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-CLCN7 antibody used in Western Blot (WB). GTX00807

GTX00807 WB Image

WB analysis of A549 cell lysate using GTX00807 CLCN7 antibody. The lane on the left was treated with the antigen-specific peptide.

Anti-CLCN7 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX00807

GTX00807 ICC/IF Image

ICC/IF analysis of PFA-fixed A549 cells using GTX00807 CLCN7 antibody.
Permeabilization : 0.1% Triton X-100
Dilution : 1:200

REFERENCE

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REVIEW

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Package List Price ($)
$ 329