GeneTex
United States (US)

COMT antibody

Anti-COMT antibody used in IHC (Paraffin sections) (IHC-P). GTX33108
Anti-COMT antibody used in IHC (Paraffin sections) (IHC-P). GTX33108
Anti-COMT antibody used in Western Blot (WB). GTX33108

Cat No. GTX33108

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

30 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 0.02% sodium azide, 50% glycerol.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 42-221 of human COMT (NP_009294.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Catechol-O-Methyltransferase,Hel-S-98N,Comt

Background

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]

Database

Research Area

DATA IMAGES
Anti-COMT antibody used in IHC (Paraffin sections) (IHC-P). GTX33108

GTX33108 IHC-P Image

IHC-P analysis of rat kidney tissue using GTX33108 COMT antibody.
Dilution : 1:100

Anti-COMT antibody used in IHC (Paraffin sections) (IHC-P). GTX33108

GTX33108 IHC-P Image

IHC-P analysis of mouse kidney tissue using GTX33108 COMT antibody.
Dilution : 1:100

Anti-COMT antibody used in Western Blot (WB). GTX33108

GTX33108 WB Image

WB analysis of various samples using GTX33108 COMT antibody.
Dilution : 1:1000
Loading : 25μg per lane

Package List Price ($)
$ 329