APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:500 - 1:1000 |
| 1:20 - 1:100 |
| 1:20 - 1:50 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 244-503 of human CYP3A4 (NP_059488.2).
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
cytochrome P450 family 3 subfamily A member 4 , CP33 , CP34 , CYP3A , CYP3A3 , CYPIIIA3 , CYPIIIA4 , HLP , NF-25 , P450C3 , P450PCN1
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]
Database
Research Area
DATA IMAGES
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GTX53947 IHC-P Image
IHC-P analysis of human liver tissue using GTX53947 CYP3A4 antibody.
Dilution : 1:100
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GTX53947 IHC-P Image
IHC-P analysis of mouse liver tissue using GTX53947 CYP3A4 antibody.
Blue : DAPI
Dilution : 1:100
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GTX53947 WB Image
WB analysis of various sample lysates using GTX53947 CYP3A4 antibody.
Dilution : 1:1000
Loading : 25μg per lane
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GTX53947 ICC/IF Image
ICC/IF analysis of U2OS cells using GTX53947 CYP3A4 antibody.
Blue : DAPI
Dilution : 1:100
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GTX53947 IHC-P Image
IHC-P analysis of mouse liver tissue using GTX53947 CYP3A4 antibody.
Dilution : 1:100
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GTX53947 IHC-P Image
IHC-P analysis of rat ovary tissue using GTX53947 CYP3A4 antibody.
Dilution : 1:100
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REFERENCE
There are currently no references for CYP3A4 antibody (GTX53947). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for CYP3A4 antibody (GTX53947). Be the first to share your experience with this product.
