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Caspase 3 antibody

KO/KD Orthogonal IP/MS
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Anti-Caspase 3 antibody used in IHC (Paraffin sections) (IHC-P). GTX110543
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Anti-Caspase 3 antibody used in Immunoprecipitation (IP). GTX110543
Anti-Caspase 3 antibody used in IHC (Paraffin sections) (IHC-P). GTX110543
Anti-Caspase 3 antibody used in IHC (Paraffin sections) (IHC-P). GTX110543
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543

Cat. No. GTX110543

Reference 134
9

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, IHC-Fr, IP, Dot

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399),
25 μl ($169)
See all Caspase 3 products
PRODUCT

Summary

Caspase 3 antibody detects caspase 3 protein, a 32 kDa zymogen (also known as pro-caspase 3) that is cleaved at conserved aspartic residues into 17 kDa and 12 kDa subunits upon activation. The cleaved subunits then form an active heterotetramer by hydrophobic interactions and trigger subsequent caspase cascades to induce the apoptotic phenotype.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:10000
IHC-P 1:100-1:1000
IHC-Fr Assay dependent
IP 1:100-1:500
Dot Assay dependent
Not tested in other applications.

Calculated MW

32 kDa. ( Note )

Positive Control

Jurkat , Raji , NCI-H929 , C8D30 , NIH-3T3 , Raw264.7 , C2C12 , PC-12 (30uM cisplatin treatment for 24h) , HeLa

Product Note

IP/MS validation was supported by references (PMID:30377401)

Predict Reactivity

Rabbit, Bovine, Cat, Pig, Chimpanzee(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA, 20% Glycerol

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.15 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human Caspase 3. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_10722709

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

caspase 3 , CPP32 , CPP32B , SCA-1

Cellular Localization

Cytoplasm

Background

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543

GTX110543 WB Image

KO/KD

Wild-type (WT) and Caspase 3 knockout (KO) HeLa cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Caspase 3 antibody (GTX110543) diluted at 1:5000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543

GTX110543 WB Image

KO/KD

Non-transfected (–) and transfected (+) HeLa whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Caspase 3 antibody (GTX110543) diluted at 1:4000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543

GTX110543 WB Image

Whole cell extract (30 μg) was separated by 12% SDS-PAGE, and the membrane was blotted with Caspase 3 antibody (GTX110543) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543

GTX110543 WB Image

Various whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Caspase 3 antibody (GTX110543) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Caspase 3 antibody used in IHC (Paraffin sections) (IHC-P). GTX110543

GTX110543 IHC-P Image

Caspase 3 antibody detects Caspase 3 protein at cytoplasm in rat liver by immunohistochemical analysis.
Sample: Paraffin-embedded rat liver.
Caspase 3 antibody (GTX110543) diluted at 1:500.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543

GTX110543 WB Image

Caspase 3 antibody detects Caspase 3 protein by western blot analysis.
A. 30 μg Jurkat whole cell lysate/extract
B. 30 μg Raji whole cell lysate/extract
C. 30 μg NCI-H929 whole cell lysate/extract
12% SDS-PAGE
Caspase 3 antibody (GTX110543) dilution: 1:5000
The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543

GTX110543 WB Image

Orthogonal

Caspase 3 antibody detects Caspase 3 protein by western blot analysis. Un-treated (-) and treated (+, 30 μM Cisplatin treatment for 24 hrs) PC-12 whole cell extracts (30 μg) were separated by 15% SDS-PAGE, and the membrane was blotted with Caspase 3 antibody (GTX110543) diluted by 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Caspase 3 antibody used in Immunoprecipitation (IP). GTX110543

GTX110543 IP Image

Immunoprecipitation of Caspase 3 protein from HeLa whole cell extracts using 5 μg of Caspase 3 antibody (GTX110543).
Western blot analysis was performed using Caspase 3 antibody (GTX110543).
EasyBlot anti-Rabbit IgG (GTX221666-01) was used as a secondary reagent.

Anti-Caspase 3 antibody used in IHC (Paraffin sections) (IHC-P). GTX110543

GTX110543 IHC-P Image

Caspase 3 antibody detects Caspase 3 protein at cytoplasm by immunohistochemical analysis.
Sample: Paraffin-embedded mouse duodenum.
Caspase 3 stained by Caspase 3 antibody (GTX110543) diluted at 1:1000.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-Caspase 3 antibody used in IHC (Paraffin sections) (IHC-P). GTX110543

GTX110543 IHC-P Image

Caspase 3 antibody detects Caspase 3 protein by immunohistochemical analysis.
Sample: Paraffin-embedded rat tissues.
Caspase 3 stained by Caspase 3 antibody (GTX110543) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543

GTX110543 WB Image

Orthogonal

Untreated (–) and treated (+) HeLa whole cell extract (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Caspase 3 antibody (GTX110543) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543

GTX110543 WB Image

Various whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Caspase 3 antibody (GTX110543) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543

GTX110543 WB Image

Orthogonal

The data was published in the 2020 in Theranostics. PMID: 32550910

Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543

GTX110543 WB Image

Orthogonal

The data was published in the 2019 in PLoS Pathog. PMID: 31841561

Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543

GTX110543 WB Image

Orthogonal

The data was published in the journal PLoS One in 2017. PMID: 29045486

Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543

GTX110543 WB Image

Orthogonal

The data was published in the journal Toxins (Basel) in 2013. PMID: 24335753

Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543

GTX110543 WB Image

Orthogonal

The data was published in the journal Oncotarget in 2016. PMID: 26716417

Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543

GTX110543 WB Image

Orthogonal

The data was published in the journal Oncotarget in 2017. PMID: 28467781

Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543

GTX110543 WB Image

Orthogonal

The data was published in the 2019 in Int J Mol Sci. PMID: 31717306

Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543

GTX110543 WB Image

Orthogonal

The data was published in the journal Nutrients in 2019.PMID: 31905929

Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543

GTX110543 WB Image

Orthogonal

The data was published in the journal Sci Rep in 2017.PMID: 28928421

Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543

GTX110543 WB Image

Orthogonal

The data was published in the journal Stem Cell Res Ther in 2017.PMID: 28482861

Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543

GTX110543 WB Image

Orthogonal

The data was published in the journal Biomolecules in 2020.PMID: 32635653

REFERENCE

Application Reference

LG Li et al. J Cancer Res Clin Oncol 2024; 150 (10) : 460 Mitochondrial disruption resulting from Cepharanthine-mediated TOM inhibition triggers ferroptosis in colorectal cancer cells
A Das et al. Transl Oncol 2024; 49 : 102107 Unraveling the chemotherapeutic potential of taxifolin ruthenium-p-cymene complex in breast carcinoma: Insights into AhR signaling pathway in vitro and in vivo
CC Liao et al. Research Square 2024; G-cleave LC3B Biosensor: Monitoring Autophagy and Assessing Resveratrol's Synergistic Impact on Doxorubicin-Induced Apoptosis in Breast Cancer Cells
Application : WB
Kaneguchi A et al. Acta Histochem Cytochem 2024; 57 (1) : 15-24 Effects of Weight Bearing on Marrow Adipose Tissue and Trabecular Bone after Anterior Cruciate Ligament Reconstruction in the Rat Proximal Tibial Epiphysis.
Demyashkin G et al. Int J Mol Sci 2024; 25 (2) Comparative Characterisation of Proliferation and Apoptosis of Colonic Epithelium after Electron Irradiation with 2 GY and 25 GY.
Show More +
Submit a Reference

REVIEW

Caspase 3 antibody Cat. No. GTX110543

Rating
( Average 4.2 based on 9 users reviews)
Application
Western Blot(WB)
( Average 4.1 based on 8 users reviews)
IHC (Paraffin sections)(IHC-P)
( Average 5 based on 1 users reviews)
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Date : Anonymous submitted on 14-Feb-2023
Score :
Application Tested : WB
Sample Species : Hu
Sample : H1299 cell lysates
Blocking : HyBlock 1min Blocking Buffer, 25°C, 0.01Hr
Primary Antibody : 1:1000, 15°C, 4Hr
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Date : Anonymous submitted on 14-May-2021
Score :
Application Tested : WB
Sample Species : Hu
Sample : A549 cells
Amount used : 5 μL
Blocking : 3% BSA in TBST, 4°C, 1Hr
Primary Antibody : 1:10000, 4°C, 16Hr
Anti-Caspase 3 antibody used in IHC (Paraffin sections) (IHC-P). GTX110543
Date : Anonymous submitted on 28-Dec-2020
Score :
Application Tested : IHC-P
Sample Species : Rat
Sample : Injured rat spinal cord tissue
Blocking : 1% BSA in PBS, 25°C, 1Hr
Fixation : 4% PFA
Permeabilization /Antigen retrieval : Commercial antigen retrieval buffer (pH 7.0)
Primary Antibody : 1:100, 4°C, 24Hr
Figure Note : Green: Caspase 3, Blue: DAPI
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Date : Anonymous submitted on 27-Dec-2020
Score :
Application Tested : WB
Sample Species : Hu
Sample : Luc-MKN45 cells
Amount used : 20 μg
Blocking : 5%FBS in 0.1%PBST, 25°C, 1Hr
Primary Antibody : 1:1000, 4°C, 16Hr
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Date : Anonymous submitted on 22-Jun-2020
Score :
Application Tested : WB
Sample Species : Hu
Sample : HEK293 cells
Amount used : 20 μg
Blocking : 5% non-fat milk in TBST, 22°C, 1Hr
Primary Antibody : 1:3000, 4°C, 16Hr
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Date : Anonymous submitted on 26-May-2018
Score :
Application Tested : WB
Sample Species : Hu
Sample : MG63 cells
Amount used : 30 μg
Blocking : 5% non-fat dry milk in TBST, 25°C, 1Hr
Primary Antibody : 1:1000, 4°C, 16Hr
Lane Description : Lane 1: Untreated MG63 whole cell lysate, Lane 2: Treated (IOX-1; 3uM) MG63 whole cell lysate, Lane 3: Treated (IOX-1; 10uM) MG63 whole cell lysateA:Untreated MG63 whole cell lysate
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Date : Anonymous submitted on 04-Jan-2016
Score :
Application Tested : WB
Sample Species : Hu
Sample : Mahlavu cells
Amount used : 50μg
Blocking : 5% milk in TBST, 25°C, 1Hr
Primary Antibody : 1:2000, 4°C, 16Hr
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Date : Anonymous submitted on 07-Jul-2015
Score :
Application Tested : WB
Sample Species : Rat
Sample : C6 cells
Amount used : 30μg
Blocking : 5% milk, 37°C, 1Hr
Primary Antibody : 1:1000, 4°C, 8Hr
Anti-Caspase 3 antibody used in Western Blot (WB). GTX110543
Date : Anonymous submitted on 09-Dec-2014
Score :
Application Tested : WB
Sample Species : Hu
Sample : PA-1 cells
Amount used : 50μg
Blocking : 5% milk, 25°C, 0.5Hr
Primary Antibody : 1:1000, 4°C, 16Hr
Show More +
Submit a Review
Application Reference
LG Li et al. J Cancer Res Clin Oncol 2024; 150 (10):460 Mitochondrial disruption resulting from Cepharanthine-mediated TOM inhibition triggers ferroptosis in colorectal cancer cells
A Das et al. Transl Oncol 2024; 49:102107 Unraveling the chemotherapeutic potential of taxifolin ruthenium-p-cymene complex in breast carcinoma: Insights into AhR signaling pathway in vitro and in vivo
CC Liao et al. Research Square 2024; G-cleave LC3B Biosensor: Monitoring Autophagy and Assessing Resveratrol's Synergistic Impact on Doxorubicin-Induced Apoptosis in Breast Cancer Cells
Application : WB
Kaneguchi A et al. Acta Histochem Cytochem 2024; 57 (1):15-24 Effects of Weight Bearing on Marrow Adipose Tissue and Trabecular Bone after Anterior Cruciate Ligament Reconstruction in the Rat Proximal Tibial Epiphysis.
Sun Q et al. Bone Rep 2024; 20:101744 Strontium ranelate retards disc degradation and improves endplate and bone micro-architecture in ovariectomized rats with lumbar fusion induced - Adjacent segment disc degeneration.
Demyashkin G et al. Int J Mol Sci 2024; 25 (2) Comparative Characterisation of Proliferation and Apoptosis of Colonic Epithelium after Electron Irradiation with 2 GY and 25 GY.
Cao M et al. Toxicol Res 2023; 39 (3):455-475 Ruthenium biochanin-A complex ameliorates lung carcinoma through the downregulation of the TGF-β/PPARγ/PI3K/TNF-α pathway in association with caspase-3-mediated apoptosis.
Z Zhao et al. BMC Complement Med Ther 2023; 23 (1):318 Anticancer potential of Bacillus coagulans MZY531 on mouse H22 hepatocellular carcinoma cells via anti-proliferation and apoptosis induction
Application : WB
Demyashkin GA et al. J Reprod Infertil 2023; 24 (2):94-100 The Influence of Platelet-Derived Growth Factors on the Proliferation of Germinal Epithelium After Local Irradiation with Electrons.
Jia L et al. Sci Rep 2023; 13 (1):14057 4-PBA inhibits endoplasmic reticulum stress to improve autophagic flux in the treatment of protamine/lipopolysaccharide-induced interstitial cystitis in rats.
Zhao M et al. iScience 2023; 26 (9):107544 IL-30 protects against sepsis-induced myocardial dysfunction by inhibiting pro-inflammatory macrophage polarization and pyroptosis.
Hsia Y et al. Int J Nanomedicine 2023; 18:4253-4274 A Dual Concentration-Tailored Cytokine-Chemo Nanosystem to Alleviate Multidrug Resistance and Redirect Balance of Cancer Proliferation and Apoptosis.
Mengmeng Zhao et al. ISCIENCE 2023; S2589-0042 (23):01621-8 IL-30 protects against sepsis-induced myocardial dysfunction by inhibiting proinflammatory macrophage polarization and pyroptosis
Application : WB
Reactivity : Mouse
E Fletcher et al. Transl Res 2023; S1931-5244 (23):00088-9 Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of peripheral artery disease
Application : WB
Chen Q et al. Chin Med 2023; 18 (1):68 Identification of Fangjihuangqi Decoction as a late-stage autophagy inhibitor with an adjuvant anti-tumor effect against non-small cell lung cancer.
Huang C et al. Pharmaceuticals (Basel) 2023; 16 (5) α-Viniferin-Induced Apoptosis through Downregulation of SIRT1 in Non-Small Cell Lung Cancer Cells.
PL Hsu et al. Sci Adv 2023; 9 (15):eade3422 Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis
Application : WB
Chen HA et al. Pharmaceutics 2023; 15 (1)
Application : WB
Reactivity : Human
Kwon J et al. iScience 2023; 26 (3):106161 Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes.
Application : WB
Reactivity : Human
Li Y et al. Exp Ther Med 2022; 24 (3):567 Interleukin 32 participates in cardiomyocyte-induced oxidative stress, inflammation and apoptosis during hypoxia/reoxygenation via the NOD2/NOX2/MAPK signaling pathway.
Application : WB
Reactivity : Human
Silva JV et al. Int J Mol Sci 2022; 23 (19) Effects of Age and Lifelong Moderate-Intensity Exercise Training on Rats' Testicular Function.
Application : Dot
Reactivity : Rat
Wu DD et al. iScience 2022; 25 (12):105459
Shichao Li et al. Mol Neurobiol 2022; 59 (7):3996-4014 LncRNA BIRF Promotes Brain Ischemic Tolerance Induced By Cerebral Ischemic Preconditioning Through Upregulating GLT-1 via Sponging miR-330-5p.
Application : WB
Reactivity : Rat
Carla Proserpio et al. Cancers (Basel) 2022; 14 (9) MEOX2 Regulates the Growth and Survival of Glioblastoma Stem Cells by Modulating Genes of the Glycolytic Pathway and Response to Hypoxia.
Application : WB
Reactivity : Human
Huanzhou Xu et al. Virology 2022; 568:13-22 SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway.
Application : WB
Reactivity : Human
Lin TE et al. J Enzyme Inhib Med Chem 2022; 37 (1):226-235 Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitors.
Application : WB
Reactivity : Human
Lai YH et al. FASEB J 2021; 35 (1):e21200 Thrombospondin 1-induced exosomal proteins attenuate hypoxia-induced paraptosis in corneal epithelial cells and promote wound healing
Application : WB
Reactivity : Human
Kan Fujino et al. J Virol 2021; 95 (14):e0203020 A Human Endogenous Bornavirus-Like Nucleoprotein Encodes a Mitochondrial Protein Associated with Cell Viability.
Kuo-Hao Ho et al. Neurotherapeutics 2021; 18 (2):1371-1392 Guanabenz Sensitizes Glioblastoma Cells to Sunitinib by Inhibiting GADD34-Mediated Autophagic Signaling.
Application : WB
Reactivity : Human
Yi-Chun Chao et al. Int J Mol Sci 2021; 22 (11) Melatonin Downregulates PD-L1 Expression and Modulates Tumor Immunity in KRAS-Mutant Non-Small Cell Lung Cancer.
Application : WB
Reactivity : Human, Mouse
Tsai YZ et al. Nutrients 2021; 13 (12) Tetrahydrocurcumin Upregulates the Adiponectin-AdipoR Pathway and Improves Insulin Signaling and Pancreatic β-Cell Function in High-Fat Diet/Streptozotocin-Induced Diabetic Obese Mice.
Application : IHC-P
Reactivity : Mouse
Tsai MF et al. Antioxidants (Basel) 2021; 10 (11) Shikonin Induced Program Cell Death through Generation of Reactive Oxygen Species in Renal Cancer Cells.
Application : WB
Reactivity : Human
Wei B et al. J Immunol Res 2021; 2021:8512200 Transcriptome Analysis of Large to Giant Congenital Melanocytic Nevus Reveals Cell Cycle Arrest and Immune Evasion: Identifying Potential Targets for Treatment.
Application : IHC-P
Reactivity : Human
Lin C.Y. et al. Natural Product Communications 2021; (Epub) Tanshinone IIA Shows Higher Antiproliferative Activities than Sinapic Acid in 4 Cancer Cell Lines and Simultaneously Induces Apoptosis and Necroptosis in Human Lung Cancer A549 Cells.
Application : WB
Reactivity : Human
Mesquita MQ et al. J Photochem Photobiol B 2021; 223:112301 Photodynamic therapy of prostate cancer using porphyrinic formulations.
Application : WB
Reactivity : Human
Chu YC et al. Mar Drugs 2021; 19 (8) Anti-Cancer and Anti-Inflammatory Activities of Three New Chromone Derivatives from the Marine-Derived Penicillium citrinum.
Liang YH et al. Sci Rep 2021; 11 (1):14720 Embelin downregulated cFLIP in breast cancer cell lines facilitate anti-tumor effect of IL-1β-stimulated human umbilical cord mesenchymal stem cells.
Application : WB
Reactivity : Human
Lam HYP et al. PLoS Negl Trop Dis 2021; 15 (6):e0009554 Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.
Application : WB
Reactivity : Mouse
Inturi R. et al. Virology 2021; 562:92-102 CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells.
Application : WB
Reactivity : Human
Zhang J et al. Mediators Inflamm 2021; 2021:6611085 Anti-Interleukin-16-Neutralizing Antibody Attenuates Cardiac Inflammation and Protects against Cardiac Injury in Doxorubicin-Treated Mice.
Application : WB
Reactivity : Mouse
Wu W et al. mBio 2021; 12 (3):e0100521 Caspase-Dependent Cleavage of DDX21 Suppresses Host Innate Immunity.
Qi Y et al. Cancer Cell Int 2021; 21 (1):74
Application : WB
Reactivity : Human
Terasaki M et al. Cancer Genomics Proteomics 2021; 18 (2):133-146 A Fucoxanthinol Induces Apoptosis in a Pancreatic Intraepithelial Neoplasia Cell.
Application : WB
Reactivity : Mouse
Chu YC et al. Mar Drugs 2021; 19 (1) Rare Chromone Derivatives from the Marine-Derived Penicillium citrinum with Anti-Cancer and Anti-Inflammatory Activities.
Application : WB
Reactivity : Human
Lam HYP et al. Parasitol Int 2021; 80:102231 Mitochondrial dynamics in Angiostrongylus cantonensis-infected mouse brain.
Application : WB
Reactivity : Mouse
Hossain KFB et al. Ecotoxicol Environ Saf 2021; 207:111320 Zinc-pretreatment triggers glutathione and Nrf2-mediated protection against inorganic mercury-induced cytotoxicity and intrinsic apoptosis in PC12?cells.
Application : WB
Reactivity : Rat
Lam HYP et al. Biomolecules 2020; 10 (7) Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice.
Kuo TT et al. ACS Omega 2020; 5 (49):31792-31800 Melissa officinalis Extract Induces Apoptosis and Inhibits Migration in Human Colorectal Cancer Cells.
Application : WB
Reactivity : Human
Yan J et al. Life Sci 2020; 263:118586 Carbon ion combined with tigecycline inhibits lung cancer cell proliferation by inducing mitochondrial dysfunction.
Application : WB
Reactivity : Human
Suarsana IN et al. Vet World 2020; 13 (8):1510-1516 Tempe extract reduces cell damage in the liver and kidneys after intensive physical exercise in rats.
Application : IHC-P
Reactivity : Mouse
Huang YY et al. BMC Vet Res 2020; 16 (1):193 Inhibiting autophagy potentiates the antitumor efficacy of Euphorbia royleana for canine mammary gland tumors.
Application : WB
Jia W et al. Theranostics 2020; 10 (15):6886-6897 Gadofullerene nanoparticles for robust treatment of aplastic anemia induced by chemotherapy drugs.
Application : WB
Reactivity : Rat
Hsu WH et al. Aging (Albany NY) 2020; 12 (11):10556-10577 T1-11, an adenosine derivative, ameliorates aging-related behavioral physiology and senescence markers in aging mice.
Application : WB
Reactivity : Human
De Luna N et al. Sci Rep 2020; 10 (1):4308 Downregulation of miR-335-5P in Amyotrophic Lateral Sclerosis Can Contribute to Neuronal Mitochondrial Dysfunction and Apoptosis.
Application : WB
Reactivity : Human
Chang HL et al. Int J Med Sci 2020; 17 (7):939-945 The Extracts of Astragalus membranaceus Overcome Tumor Immune Tolerance by Inhibition of Tumor Programmed Cell Death Protein ligand-1 Expression.
Application : WB
Reactivity : Mouse
Binte Hossain KF et al. Ecotoxicol Environ Saf 2020; 192:110238 Regulatory effects of dihydrolipoic acid against inorganic mercury-mediated cytotoxicity and intrinsic apoptosis in PC12?cells.
Application : WB
Reactivity : Rat
Xiao L et al. Nano Lett 2020; 20 (1):478-495 Dihydrolipoic Acid-Gold Nanoclusters Regulate Microglial Polarization and Have the Potential To Alter Neurogenesis.
Application : WB
Reactivity : Mouse
Xu H et al. PLoS Pathog 2019; 15 (12):e1008228 Novel replisome-associated proteins at cellular replication forks in EBV-transformed B lymphocytes.
Lu CC et al. Int J Oncol 2019; 54 (4):1271-1281
Lee CW et al. Nutrients 2019; 12 (1) Synbiotic Combination of Djulis (Chenopodium formosanum) and Lactobacillus acidophilus Inhibits Colon Carcinogenesis in Rats.
Application : WB
Reactivity : Rat
Rahaman MS et al. Environ Toxicol Pharmacol 2019; 74:103302 Investigating the protective actions of D-pinitol against arsenic-induced toxicity in PC12 cells and the underlying mechanism.
Application : WB
Reactivity : Rat
Gupta R et al. Free Radic Biol Med 2019; 134:630-643 An augmentation in histone dimethylation at lysine nine residues elicits vision impairment following traumatic brain injury.
Reactivity : Mouse
Tomoyuki Kurose et al. Stem Cell Research 2019; (Epub) Simulated microgravity-cultured mesenchymal stem cells improve recovery following spinal cord ischemia in rats.
Application : IHC-P
Reactivity : Rat
Wang CY et al. Int J Mol Sci 2019; 20 (22) N-Dihydrogalactochitosan Potentiates the Radiosensitivity of Liver Metastatic Tumor Cells Originated from Murine Breast Tumors.
Application : WB
Li SC et al. Nutrients 2019; 11 (11) Lactobacillus acidophilus-Fermented Germinated Brown Rice Suppresses Preneoplastic Lesions of the Colon in Rats.
Application : WB
Reactivity : Rat
Dario Rizzotto et al. bioRxiv 2019; (Epub) p53-induced apoptosis is specified by a translation program regulated by PCBP2 and DHX30.
Application : WB
Reactivity : Human
Banik S et al. Food Chem Toxicol 2019; 134:110835 Carvacrol inhibits cadmium toxicity through combating against caspase dependent/independent apoptosis in PC12?畚ells.
Application : WB
Reactivity : Rat
Kurniawan AL et al. Food Funct 2019; 10 (7):4113-4123 Alteration in iron efflux affects male sex hormone testosterone biosynthesis in a diet-induced obese rat model.
Application : WB
Reactivity : Rat
Yu WN et al. In Vivo 2019; 33 (4):1193-1201 Citronellol Induces Necroptosis of Human Lung Cancer Cells via TNF-α Pathway and Reactive Oxygen Species Accumulation.
Application : WB
Reactivity : Human
Wei GJ et al. AAPS J 2019; 21 (5):86 A Tangeretin Derivative Inhibits the Growth of Human Prostate Cancer LNCaP Cells by Epigenetically Restoring p21 Gene Expression and Inhibiting Cancer Stem-like Cell Proliferation.
Application : WB
Reactivity : Human
Yu-Jen Lu et al. Chemical Engineering Journal 2019; 373:720-733 Thermosensitive magnetic liposomes for alternating magnetic field-inducible drug delivery in dual targeted brain tumor chemotherapy.
Application : WB
Reactivity : Human
Fararjeh AS et al. Cancers (Basel) 2019; 11 (4) Proteasome 26S Subunit, non-ATPase 3 (PSMD3) Regulates Breast Cancer by Stabilizing HER2 from Degradation.
Application : WB
Reactivity : Human
Gazzano E et al. Cancer Lett 2019; 456:29-39 Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive/doxorubicin-resistant osteosarcoma cells and xenografts.
Application : WB
Reactivity : Mouse
Yuan F et al. Cancer Lett 2019; 446:1-14 TIPE3 is a regulator of cell apoptosis in glioblastoma.
Application : WB
Reactivity : Human
El-Sayed RM et al. Can J Physiol Pharmacol 2019; 97 (5):359-369
Application : IHC-P
Reactivity : Mouse
Tew LS et al. Materials (Basel) 2018; 11 (7) Pollen-Structured Gold Nanoclusters for X-ray Induced Photodynamic Therapy.
Lee CW et al. J Cell Physiol 2018; (Epub) Artocarpin induces cell apoptosis in human osteosarcoma cells through endoplasmic reticulum stress and reactive oxygen species.
Application : WB
Reactivity : Human
Buondonno I et al. Cell Mol Life Sci 2018; (Epub) endoplasmic reticulum-targeting *: a new tool effective against *-resistant osteosarcoma.
Application : WB
Reactivity : Human
Sikorski K et al. Nat Methods 2018; 15 (11):909-912 A high-throughput pipeline for validation of antibodies.
Application : IP
Reactivity : Human
Cheng CL et al. Eur J Pharmacol 2018; 840:79-88 Escin induces apoptosis in human bladder cancer cells: An in vitro and in vivo study.
Application : WB
Reactivity : Mouse
Ugun-Klusek A et al. Redox Biol. 2018; 20:167-181. Monoamine oxidase-A promotes protective autophagy in human SH-SY5Y neuroblastoma cells through Bcl-2 phosphorylation.
Application : WB
Reactivity : Human
Lee CF et al. Biomedicine (Taipei) 2018; 8 (3):15 benzyl isothiocyanate (bitc) triggers mitochondria-mediated apoptotic machinery in human *-resistant oral cancer car cells.
Application : WB
Reactivity : Human
Chen Y et al. Biosci Rep 2018; 38 (5) gandouling combined with * improves cerebrovascular injury via perk/eif2α/chop endoplasmic reticulum stress pathway in the mouse model of wilson's disease.
Application : WB
Reactivity : Mouse
Ho Y et al. Food Chem Toxicol 2018; 120:346-355 Resveratrol inhibits human leiomyoma cell proliferation via crosstalk between integrin αvβ3 and IGF-1R.
Application : WB
Reactivity : Human
Huang KF et al. J Cell Physiol 2018; (Epub) A new copper ionophore DPMQ protects cells against ultraviolet B irradiation by inhibiting the TRPV1 channel.
Application : WB
Reactivity : Human
Terasaki M et al. Anticancer Res 2018; 38 (4):2169-2179 Glycine Is a Predictor for a Suppressive Effect of Fucoxanthinol on Colonosphere Formation Under Hypoxia.
Application : WB
Reactivity : Human
Kopecka J et al. Lung Cancer 2018; 120:34-45 loss of c/ebp-β lip drives * resistance in malignant pleural mesothelioma.
Application : WB
Reactivity : Human
Chen PY et al. Int J Mol Sci 2018; 19 (4) Response of Myeloid Leukemia Cells to Luteolin is Modulated by Differentially Expressed Pituitary Tumor-Transforming Gene 1 (PTTG1) Oncoprotein.
Application : WB
Reactivity : Human
Kim SH et al. Biomedicine & Pharmacotherapy 2018; 99:997-1008 Teroxirone suppresses growth and motility of human hepatocellular carcinoma cells.
Application : WB
Reactivity : Human
Chang HP et al. Int J Oncol 2018; (Epub) pterostilbene modulates the suppression of multidrug resistance protein-1 and triggers autophagic and apoptotic mechanisms in *-resistant human oral cancer car cells via akt signaling.
Application : WB
Reactivity : Human
Eoh KJ et al. Biochem Biophys Res Commun 2018; (Epub) MicroRNA-630 inhibitor sensitizes chemoresistant ovarian cancer to chemotherapy by enhancing apoptosis.
Application : WB
Reactivity : Human
Lin KT et al. Am J Chin Med 2018;:43116 Rhodiola crenulata Attenuates γ-Ray Induced Cellular Injury Via Modulation of Oxidative Stress in Human Skin Cells.
Application : WB
Reactivity : Human
Yang JS et al. Oncol Rep 2018; 39 (1):383-391 ITR-284 modulates cell differentiation in human chronic myelogenous leukemia K562 cells.
Li J et al. Stem Cell Res Ther 2017; 8 (1):107 therapeutic effect of urine-derived stem cells for */lipopolysaccharide-induced interstitial cystitis in a rat model.
Wu DD et al. Oncotarget 2017; 8 (30):49144-49155 extracellular signal-regulated kinase 8-mediated nf-κb activation increases sensitivity of human lung cancer cells to *.
Jin L et al. Int J Mol Med 2017; (Epub) Effects of ERK1/2 S-nitrosylation on ERK1/2 phosphorylation and cell survival in glioma cells.
Lee SO et al. J Ginseng Res 2017; (Epub) Korean red ginseng enhances pneumococcal Δpep27 vaccine efficacy by inhibiting reactive oxygen species production.
Application : WB
Reactivity : Mouse
Su WC et al. J Virol 2017; (Epub) Ubiquitination of the Cytoplasmic Domain of Influenza A Virus M2 Protein is Crucial for Production of Infectious Virus Particles.
Zera K et al. PLoS One 2017; 12 (10):e0186707 Thiamine deficiency activates hypoxia inducible factor-1α to facilitate pro-apoptotic responses in mouse primary astrocytes.
Application : WB
Reactivity : Mouse
Li SM et al. Sci Rep 2017; 7 (1):11893 Upregulation of CISD2 augments ROS homeostasis and contributes to tumorigenesis and poor prognosis of lung adenocarcinoma.
Application : WB
Reactivity : Human
Lee WY et al. Int J Cancer 2017; 141 (9):1921-1931 * sensitizes kras-mutant non-small-cell lung cancer to * by targeting taz.
Application : WB
Reactivity : Human
Zubair H et al. Nutr Cancer 2017;:43111 Hydroxytyrosol Induces Apoptosis and Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells.
Sun Y et al. Exp Cell Res 2017; (Epub) High-glucose induces tau hyperphosphorylation through activation of TLR9-P38MAPK pathway.
Application : WB
Reactivity : Mouse
Lee CC et al. Sci Rep 2017; 7 (1):7290 4β-Hydroxywithanolide E Modulates Alternative Splicing of Apoptotic Genes in Human Hepatocellular Carcinoma Huh-7 Cells.
Application : WB
Reactivity : Human
Huang YC et al. Toxicol Appl Pharmacol 2017; 329:128-139 galangin ameliorates *-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death in mice through inhibition of erk and nf-kappab signaling.
Application : WB
Reactivity : Mouse
Gao Z et al. Hindawi 2017; (Epub) Dab1 contributes to angiotensin II-induced apoptosis via p38 signaling pathway in podocytes.
Application : WB
Reactivity : Mouse
Hung CC et al. Head Neck 2017; (Epub) differential resistance to platinum-based drugs and 5-* in p22phox-overexpressing oral squamous cell carcinoma: implications of alternative treatment strategies.
Application : WB
Reactivity : Human
Ho CH et al. J Biol Chem 2017; (Epub) Functional and biochemical characterization of a T cell associated anti-apoptotic protein, GIMAP6.
Application : WB
Reactivity : Human
Hsu SW et al. BMC Complement Altern Med 2017; 17 (1):29 Rhodiola crenulata extract counteracts the effect of hypobaric hypoxia in rat heart via redirection of the nitric oxide and arginase 1 pathway.
Application : WB
Reactivity : Rat
Xu YM et al. Oncotarget 2016; 7 (5):6146-58 Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells.
Application : WB
Reactivity : Human
Liu Y et al. Technol Cancer Res Treat 2016; 15 (3):487-97 Effects of Oxymatrine on the Proliferation and Apoptosis of Human Hepatoma Carcinoma Cells.
Application : IHC-P
Reactivity : Mouse
Chen PH et al. Neuropharmacology 2016; (Epub) the chac1-inhibited notch3 pathway is involved in *-induced glioma cytotoxicity.
Application : WB
Reactivity : Human
Akasaka H et al. Radiat Oncol 2016; 11 (1):153 MGDG extracted from spinach enhances the cytotoxicity of radiation in pancreatic cancer cells.
Application : WB
Reactivity : Human
Zheng Y et al. Int J Biol Sci 2016; 12 (1):120-32 Photodynamic-therapy Activates Immune Response by disrupting Immunity Homeostasis of Tumor Cells, which Generates Vaccine for Cancer Therapy.
Application : WB
Reactivity : Mouse
Pellitteri R et al. Mol Neurobiol 2016; (Epub) Effect of Some Growth Factors on Tissue Transglutaminase Overexpression Induced by β-Amyloid in Olfactory Ensheathing Cells.
Reactivity : Rat
Lin CY et al. Cell Death Discov 2016; 2:16065 Simultaneous induction of apoptosis and necroptosis by Tanshinone IIA in human hepatocellular carcinoma HepG2 cells.
Application : WB
Reactivity : Human
Nehra S et al. High Alt Med Biol 2016; Chronic Hypobaric Hypoxia Induces Right Ventricular Hypertrophy and Apoptosis in Rats: Therapeutic Potential of Nanocurcumin in Improving Adaptation.
Application : IHC-Fr
Reactivity : Rat
Kuo HF et al. PLoS One 2016; 11 (5):e0156059 Pigment Epithelium-Derived Factor Mediates Autophagy and Apoptosis in Myocardial Hypoxia/Reoxygenation Injury.
Application : WB
Reactivity : Human
Y Zhang et al. Journal of Materials Chemistry B 2016; (Epub) Surface modification with E-cadherin fusion protein for mesenchymal stem cell culture.
Application : WB
Reactivity : Human
Pezzani R et al. Invest New Drugs 2016; (Epub) The aurora kinase inhibitor VX-680 shows anti-cancer effects in primary metastatic cells and the SW13 cell line.
Application : WB
Reactivity : Human
Lu JW et al. Cancer Lett 2016; (Epub) * is selectively cytotoxic in acute myeloid leukemia cells with flt3-internal tandem duplication (flt3-itd).
Application : WB
Reactivity : Human
Yuanhong Zheng et al. International Journal of Biological Sciences 2016; 12 (1):120-132 Photodynamic-therapy Activates Immune Response by disrupting Immunity Homeostasis of Tumor Cells, which Generates Vaccine for Cancer Therapy.
Application : WB
Reactivity : Mouse
Hung CC et al. Oncotarget 2015; 6 (6):4110-25 p22phox confers resistance to *, by blocking its entry into the nucleus.
Application : WB
Reactivity : Human
Chou SF et al. PLoS Pathog 2015; 11 (10):e1005123 The Dual Role of an ESCRT-0 Component HGS in HBV Transcription and Naked Capsid Secretion.
Application : WB
Reactivity : Human
Ruan Y et al. Mol Med Rep 2015; 12 (4):5796-806 Autophagy inhibition enhances isorhamnetin-induced mitochondria-dependent apoptosis in non-small cell lung cancer cells.
Lee WY et al. Oncotarget 2015; (Epub) repositioning antipsychotic * for treating colorectal cancer by inhibiting sirtuin 1.
Application : WB
Reactivity : Human
Chin YT et al. Oncotarget 2014; 5 (24):12891-907 Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro.
Application : WB
Reactivity : Human
Su ML et al. PLoS One 2014; 9 (6):e98823 Inhibition of chemokine (C-C motif) receptor 7 sialylation suppresses CCL19-stimulated proliferation, invasion and anti-anoikis.
Application : WB
Reactivity : Human
Chen PH et al. J Neurochem 2014; MicroRNA-302b-inhibited E2F3 transcription factor is related to all trans retinoic acid-induced glioma cell apoptosis.
Application : WB
Reactivity : Human
Li KC et al. Mol Cancer 2014; 13:172 Inhibition of G9a induces DUSP4-dependent autophagic cell death in head and neck squamous cell carcinoma.
Application : WB
Reactivity : Human
Lin MH et al. Chem Biol Interact 2014; 218C:42-49 Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin-derivative, DMAC, in human colon cancer cells.
Application : WB
Reactivity : Human
Wu JG et al. J Ethnopharmacol 2014; Chemical composition, antimicrobial activity against Staphylococcus aureus and a pro-apoptotic effect in SGC-7901 of the essential oil from Toona sinensis (A. Juss.) Roem. leaves.
Application : WB
Reactivity : Human
Huang SC et al. Sci Signal 2014; 7 (314):ra20 Tumor Necrosis Factor Suppresses NR5A2 Activity and Intestinal Glucocorticoid Synthesis to Sustain Chronic Colitis.
Application : WB
Reactivity : Mouse
Chang WW et al. Toxins (Basel) 2013; 5 (12):2353-65 an extract of rhodobacter sphaeroides reduces *-induced nephrotoxicity in mice.
Application : WB
Reactivity : Mouse
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