GeneTex
United States (US)

DC-SIGN antibody

Anti-DC-SIGN antibody used in IHC (Paraffin sections) (IHC-P). GTX31656
Anti-DC-SIGN antibody used in Western Blot (WB). GTX31656
Anti-DC-SIGN antibody used in IHC (Paraffin sections) (IHC-P). GTX31656

Cat No. GTX31656

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P, ELISA
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1 - 2 μg/mL
IHC-P 10 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

46 kDa. ( Note )

Positive Control

Human Lymphoid Tissue Tissue Slide(GTX21833) , Human Small Intestine Tissue Lysate(GTX27923)
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

DC-SIGN antibody was raised against a synthetic peptide corresponding to 21 amino acids near the center of human DC-DIGN.The immunogen is located within the last 50 amino acids of DC-SIGN.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Cd209 Molecule,Cdsign,Clec4L,Dc-Sign,Dc-Sign1,Cd209

Background

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant i

Database

Research Area

DATA IMAGES
Anti-DC-SIGN antibody used in IHC (Paraffin sections) (IHC-P). GTX31656

GTX31656 IHC-P Image

IHC-P analysis of human lymph node tissue using GTX31656 DC-SIGN antibody.
Working concentration : 20 μg/ml

Anti-DC-SIGN antibody used in Western Blot (WB). GTX31656

GTX31656 WB Image

WB analysis of human small intestine tissue lysate using GTX31656 DC-SIGN antibody.
Working concentration : (A) 1 and (B) 2 μg/ml

Anti-DC-SIGN antibody used in IHC (Paraffin sections) (IHC-P). GTX31656

GTX31656 IHC-P Image

IHC-P analysis of human lymph node tissue using GTX31656 DC-SIGN antibody.
Working concentration : 10 μg/ml

Package List Price ($)
$ 329