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DMP1 antibody

Anti-DMP1 antibody used in Western Blot (WB). GTX04077
Anti-DMP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX04077
Anti-DMP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX04077
Anti-DMP1 antibody used in Western Blot (WB). GTX04077

Cat. No. GTX04077

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Rat, Monkey
Package
100 μl ($399)
See all DMP1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:1000-1:3000
IHC-P 1:50-1:200
Not tested in other applications.

Calculated MW

56 kDa. ( Note )

Predict Reactivity

Rabbit, Sheep, Bovine, Dog(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 150mM NaCl, 50% Glycerol

Preservative

0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthesized peptide derived from human DMP1(Accession Q13316), corresponding to amino acid residues S488-Y513.

Purification

Purified by antigen-affinity chromatography
From serum

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

dentin matrix acidic phosphoprotein 1 , ARHP , ARHR , DMP-1

Cellular Localization

Nucleus , Cytoplasm

Background

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-DMP1 antibody used in Western Blot (WB). GTX04077

GTX04077 WB Image

WB analysis of mouse lung tissue lysates using GTX04077 DMP1 antibody. The lane on the left was treated with blocking peptide.

Anti-DMP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX04077

GTX04077 IHC-P Image

IHC-P analysis of mouse brain tissue using GTX04077 DMP1 antibody.
Antigen retrieval : Heat mediated antigen retrieval step in citrate buffer was performed
Dilution : 1:100

Anti-DMP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX04077

GTX04077 IHC-P Image

IHC-P analysis of rat brain tissue using GTX04077 DMP1 antibody.
Antigen retrieval : Heat mediated antigen retrieval step in citrate buffer was performed
Dilution : 1:100

Anti-DMP1 antibody used in Western Blot (WB). GTX04077

GTX04077 WB Image

WB analysis of COS7 cell lysate using GTX04077 DMP1 antibody.

REFERENCE

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REVIEW

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Package List Price ($)
$ 399