20 mM PBS pH-7.4 and 130 mM sodium chloride
Reconstitute in ddH2O. Store at -20ºC. Product is stable for at least 12 months.
Purity was assessed by SDS-PAGE (≥98%) and by HPLC.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Defensin Beta 1,Bd1,Defb-1,Defb101,Hbd1,Defb1
The Defensin family are highly similar in their protein sequence and are microbicidal & cytotoxic peptides made by neutrophils. beta Defensin-1 (BD-1) is an antimicrobial peptide having the resistance of epithelial surfaces to microbial colonization. BD-1 has close proximity to Defensin alpha -1 and has been implicated in the pathogenesis of cystic fibrosis. Skin of patients having atopic dermatitis patients and mycosis fungoides (non-lesional and lesional) show lower human BD-1 mRNA expression and higher human BD-2 and human BD-3 mRNA expression. beta Defensin is highly expressed by epithelial cells. BD-1 may play a role in the pathogenesis of severe sepsis. Variation in human BD-1 contributes to asthma diagnosis, with apparent gender-specific effects. Human BD-3 is a dimer, while Human BD-1 and Human BD-2 are monomeric. Recombinant human beta Defensin-1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 47 amino acids and having a molecular mass of 5 kDa.