GeneTex
United States (US)

Elovl6 antibody

GTX48702_20160330_IHC_18121410_569.jpg
Elovl6-antibody-GTX48702-WB-1_18121410_376.jpg

Cat No. GTX48702

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ELISA, IHC
Reactivity Human, Mouse, Rat, Bovine
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1.0 - 2.0 μg/mL
ELISA 1:10000 - 1:40000
IHC 5.0 μg/mL
Not tested in other applications.

Calculated MW

31 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 and 0.01% (w/v) Sodium Azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

ELOVL6 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide near the n-terminus of the human ELOVL6.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

FAE Antibody , LCE Antibody , FACE Antibody , ELOVL6 Antibody

Background

Lipogenesis is a key event in the energy storage system and is controlled by the transcription factor sterol regulatory element-binding protein (SREBP)-1. Elongation of very long chain fatty acids protein 6 (ELOVL6) is a member of fatty acyl-CoA elongase gene family that converts palmitic to stearic acid and it has been shown to be a target of SREBP-1, playing an important role in de novo synthesis of long-chain saturated and monosaturated fatty acids in conjunction with fatty acid synthase and stearoyl-CoA desaturase. ELOVL6 was predicted to be important for tissue fatty acid composition. Recent studies suggest that inhibition of this elongase could be a new therapeutic approach for ameliorating insulin resistance, diabetes and cardiovascular risks, even in the presence of a continuing state of obesity.

Database

Research Area

DATA IMAGES
GTX48702_20160330_IHC_18121410_569.jpg

GTX48702 IHC Image

Immunohistochemistry demonstrating detection of ELOVL6 in human brain tissue. Primary antibody was used at a concentration of 5.0 µg/mL.

Elovl6-antibody-GTX48702-WB-1_18121410_376.jpg

GTX48702 WB Image

Western blot analysis showing detection of ELOVL6 in human brain tissue lysate with primary antibody at 1.0 µg/mL (lane A) and 2.0 µg/ml. (lane B).

Package List Price ($)
$ 319