GeneTex
  • Country / Location Selection

United States (US)

Endomorphin 1 & 2 antibody

Anti-Endomorphin 1 & 2 antibody used in Immunohistochemistry (IHC). GTX10290

Cat No. GTX10290

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application IHC-Fr, ELISA, IHC
Reactivity Human, Mouse, Rat, Pig, Monkey
Package
50 μg ($319)
APPLICATION

Application Note

ELISA: Use at an assay dependent dilution. IHC-Fr: Use at a concentration of 3-10 μg/ml. Optimal dilutions/concentrations should be determined by the end user.

Specificity/Sensitivity

Sensitivity has been determined by ELISA. Less than 1ng of antibody could be detected after binding to Endomorphin 2 which is conjugated to titer plate:Endomorphin 2 = 100Endomorphin 1 = 70Leu5-Enkephalin = <0.01Met5-Enkephalin = <0.03beta-Endorphin = <0.01
PROPERTIES

Form

Liquid

Buffer

Restore with 50μl of dH2O containing 0.1% sodium azide or other preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Immunogen

Synthetic peptide conjugated to BSA.

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Endomorphin 1 &2

Background

Recently, endogenous agonists for the mu-opiate receptor, were first isolated from bovine brain [Nature,386, 499 (1997)]. These are endomorphin-1; Tyr-Pro-Trp-Phe-NH2, and endomorphin-2; Tyr-Pro-Phe-Phe-NH2. The isolation of relatively large amounts of endomorphin-1 and endomorphin-2 from human brain cortex has also reported [Peptides,18, 1635 (1997)].The immunoreactivity for endomorphin was also detected in rat brain near the mu-opiate receptor containing neurons, but the molecular form of the rat peptide has not yet been elucidated [Peptides,18, 1641 (1997)]. These observations may be considered to indicate that endomorphin-1 and 2 are common mu-opiate agonists in mammals. In addition to the originally discovered mu-opiate agonistic function, these peptides have been reported to show hypotensive activity and Ca2+ channel current inhibitory activity [Biochem. Biophys. Res. Commun.,235, 567 (1997)]. Endomorphins would be useful for the study of pain perception together with some other biological functions in the body.
DATA IMAGES
Anti-Endomorphin 1 & 2 antibody used in Immunohistochemistry (IHC). GTX10290

GTX10290 IHC Image

Endomorphin-1 and 2 staining in rat paraventricular thalamic nucleus.

REFERENCE
There are currently no references for Endomorphin 1 & 2 antibody (GTX10290). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for Endomorphin 1 & 2 antibody (GTX10290). Be the first to share your experience with this product.
Package List Price ($)
$ 319