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Estrogen Receptor beta antibody [14C8]

KO/KD Comparison Overexpression
Anti-Estrogen Receptor beta antibody [14C8] used in Western Blot (WB). GTX70174
Anti-Estrogen Receptor beta antibody [14C8] used in Immunohistochemistry (IHC). GTX70174
Anti-Estrogen Receptor beta antibody [14C8] used in IHC (Paraffin sections) (IHC-P). GTX70174

Cat. No. GTX70174

Reference 122
10

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 14C8

Isotype

 IgG2b

Application

 WB, ICC/IF, IHC-P, IHC-Fr, FACS, Dot, ChIP assay, IHC, IHC-P (cell pellet)

Reactivity

 Human, Mouse, Monkey
Package
100 μl ($399)
See all Estrogen Receptor beta products

APPLICATION

Application Note

For IHC, a recommended protocol is provided. For WB: Use at a concentration of 1-5 μg/ml. For ChIP: Use at an dependent assay. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

59 kDa. ( Note )

Positive Control

Myc-DDK-tagged ESR2-transfected 293T

Product Note

Strong Erb staining in epithelial cell nuclei. Occasional weak to moderate staining is seen in surrounding stromal and endothelial cell nuclei. Sporadic light cytoplasmic staining is sometimes observed. We have also successfully detected ERb in colon and ovarian tumors using the same antibody.
Knockdown/Knockout validation was supported by references (PMID:27323858)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No Preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.23 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Amino acids 1-153 of human ER-beta expressed in E. coli.

Purification

Protein G purified

Conjugation

Unconjugated

RRID

AB_370367

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

estrogen receptor 2 , ER-BETA , ESR-BETA , ESRB , ESTRB , Erb , NR3A2 , ODG8

Cellular Localization

Nucleus

Background

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Estrogen Receptor beta antibody [14C8] used in Western Blot (WB). GTX70174

GTX70174 WB Image

Non-transfected (–) and transfected (+) 293T whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with Estrogen Receptor beta antibody [14C8] (GTX70174) diluted at 1:5000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-Estrogen Receptor beta antibody [14C8] used in Immunohistochemistry (IHC). GTX70174

GTX70174 IHC Image

B. Infiltrating lobular carcinoma of the breast.

Anti-Estrogen Receptor beta antibody [14C8] used in IHC (Paraffin sections) (IHC-P). GTX70174

GTX70174 IHC-P Image

Estrogen Receptor beta antibody [14C8] detects Estrogen Receptor beta protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded human breast carcinoma.
Estrogen Receptor beta stained by Estrogen Receptor beta antibody [14C8] (GTX70174) diluted at 1:200.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

REFERENCE

Application Reference

Ariyani W et al. Int J Mol Sci 2023; 24 (10) Isoflavones Mediate Dendritogenesis Mainly through Estrogen Receptor α.
Hojnik M et al. Int J Mol Sci 2023; 24 (3) The Co-Expression of Estrogen Receptors ERα, ERβ, and GPER in Endometrial Cancer.
He Y et al. Int J Mol Sci 2022; 23 (13) Therapeutic Targeting of Ovarian Cancer Stem Cells Using Estrogen Receptor Beta Agonist.
Young MJ et al. J Biomed Sci 2022; 29 (1) : 3 Estradiol-mediated inhibition of Sp1 decreases miR-3194-5p expression to enhance CD44 expression during lung cancer progression.
Application : ChIP assay
Reactivity : Human
Uday P Pratap et al. Neurooncol Adv 2021; 3 (1) : vdab099 Histone deacetylase inhibitors enhance estrogen receptor beta expression and augment agonist-mediated tumor suppression in glioblastoma.
Application : WB, IHC-P, IHC-P (cell pellet)
Reactivity : Human
Show More +
Submit a Reference

REVIEW

Estrogen Receptor beta antibody [14C8] Cat. No. GTX70174

Rating
( Average 4.9 based on 10 users reviews)
Application
Western Blot(WB)
( Average 5 based on 6 users reviews)
Immunocytochemistry/ Immunofluorescence(ICC/IF)
( Average 4.5 based on 2 users reviews)
IHC (Paraffin sections)(IHC-P)
( Average 5 based on 2 users reviews)
Anti-Estrogen Receptor beta antibody [14C8] used in Western Blot (WB). GTX70174
Date : Anonymous submitted on 03-Oct-2022
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the 2017 in Nat Commun. PMID: 28643774
Anti-Estrogen Receptor beta antibody [14C8] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX70174
Date : Anonymous submitted on 05-Jan-2022
Score :
Application Tested : ICC/IF
Sample Species : Hu
Sample : Human dermal fibroblast
Blocking : Blocking one (Nacalai), RT, 0.5Hr
Fixation : 4% PFA in PBS
Permeabilization /Antigen retrieval : 0.1% Triton in PBS
Primary Antibody : Undiluted, 25°C, 1Hr
Anti-Estrogen Receptor beta antibody [14C8] used in IHC (Paraffin sections) (IHC-P). GTX70174
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : IHC-P
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Cancer Med in 2013. PMID: 23930207
Anti-Estrogen Receptor beta antibody [14C8] used in IHC (Paraffin sections) (IHC-P). GTX70174
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : IHC-P
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Reprod Biol Endocrinol in 2012. PMID: 22520060
Anti-Estrogen Receptor beta antibody [14C8] used in Western Blot (WB). GTX70174
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Figure Note : The data was peer reviewed and published in the journal Breast Cancer Res in 2012. PMID: 23158001
Anti-Estrogen Receptor beta antibody [14C8] used in Western Blot (WB). GTX70174
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Figure Note : The data was peer reviewed and published in the journal Breast Cancer Res in 2012. PMID: 23158001
Anti-Estrogen Receptor beta antibody [14C8] used in Western Blot (WB). GTX70174
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Figure Note : The data was peer reviewed and published in the journal Breast Cancer Res in 2012. PMID: 23158001
Anti-Estrogen Receptor beta antibody [14C8] used in Western Blot (WB). GTX70174
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Figure Note : The data was peer reviewed and published in the journal Breast Cancer Res in 2012. PMID: 23158001
Anti-Estrogen Receptor beta antibody [14C8] used in Western Blot (WB). GTX70174
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Breast Cancer Res in 2012. PMID: 23158001
Anti-Estrogen Receptor beta antibody [14C8] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX70174
Date : Anonymous submitted on 13-Feb-2019
Score :
Application Tested : ICC/IF
Sample Species : Ms
Sample : Cells differentiated from neural stem cells
Blocking : 10% goat serum in PBS, 25°C, 0.5Hr
Fixation : 4% PFA
Permeabilization /Antigen retrieval : 0.5% Tritonx-100 in PBS
Primary Antibody : 1:500, 4°C, 16Hr
Show More +
Submit a Review
Application Reference
Ariyani W et al. Int J Mol Sci 2023; 24 (10) Isoflavones Mediate Dendritogenesis Mainly through Estrogen Receptor α.
Hojnik M et al. Int J Mol Sci 2023; 24 (3) The Co-Expression of Estrogen Receptors ERα, ERβ, and GPER in Endometrial Cancer.
He Y et al. Int J Mol Sci 2022; 23 (13) Therapeutic Targeting of Ovarian Cancer Stem Cells Using Estrogen Receptor Beta Agonist.
Young MJ et al. J Biomed Sci 2022; 29 (1):3 Estradiol-mediated inhibition of Sp1 decreases miR-3194-5p expression to enhance CD44 expression during lung cancer progression.
Application : ChIP assay
Reactivity : Human
Hwa Young Ahn et al. Cancer Res Treat 2021; 53 (4):1204-1212 Expression of Estrogen and Progesterone Receptors in Papillary Thyroid Carcinoma in Korea.
Application : IHC-P
Reactivity : Human
Uday P Pratap et al. Neurooncol Adv 2021; 3 (1):vdab099 Histone deacetylase inhibitors enhance estrogen receptor beta expression and augment agonist-mediated tumor suppression in glioblastoma.
Application : WB, IHC-P, IHC-P (cell pellet)
Reactivity : Human
He M et al. Cancer Lett 2021; 524:15-28 Sunitinib increases the cancer stem cells and vasculogenic mimicry formation via modulating the lncRNA-ECVSR/ERβ/Hif2-α signaling.
Application : WB
Reactivity : Human
Thomas C et al. Cancer Res 2021; (Epub) Estrogen receptor β-mediated inhibition of actin-based cell migration suppresses metastasis of inflammatory breast cancer.
Application : WB
Lijuan Zhang et al. Front Oncol 2020; 10:603883 Estrogen Receptor β1 Expression Patterns Have Different Effects on Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors' Treatment Response in Epidermal Growth Factor Receptor Mutant Lung Adenocarcinoma.
Application : ICC/IF
Reactivity : Human
Varshney MK et al. Neuroendocrinology 2020; (Epub) Motor function deficits in the estrogen receptor beta knockout mouse: Role on excitatory neurotransmission and myelination in the motor cortex.
Application : IHC-Fr
Reactivity : Mouse
Col?n-Caraballo M et al. Appl Immunohistochem Mol Morphol 2019; 27 (7):491-500 Human Endometriosis Tissue Microarray Reveals Site-specific Expression of Estrogen Receptors, Progesterone Receptor, and Ki67.
Asavasupreechar T et al. J Steroid Biochem Mol Biol 2019; 193:105440 Sex steroid metabolism and actions in non-small cell lung carcinoma.
Fan W et al. Biochem Biophys Res Commun 2019; 511 (2):468-475 Estrogen receptors participate in carcinogenesis signaling pathways by directly regulating NOD-like receptors.
Application : ChIP assay
Reactivity : Human
Lee S et al. CNS Neurosci Ther 2018; 24 (10):930-939 Estrogen receptor-β of microglia underlies sexual differentiation of neuronal protection via ginsenosides in?mice?brain.
Kumata H et al. Hepatol Res 2018; (Epub) Steroidogenesis in ovarian-like mesenchymal stroma of hepatic and pancreatic mucinous cystic neoplasms.
Andersson S et al. Nat Commun 2017; 8:15840 Insufficient antibody validation challenges oestrogen receptor beta research.
Application : WB
Reactivity : Human
Rupp NJ et al. Breast J 2017; (Epub) Solid papillary carcinoma of the breast with an associated Cytokeratin 7- negative Paget's disease of the nipple. Report of a first case.
Application : IHC-P
Reactivity : Human
Nikolos F et al. Mol Cancer Res 2017; (Epub) ERβ Sensitizes NSCLC to Chemotherapy by Regulating DNA Damage Response.
Application : WB
Reactivity : Human
Miki Y et al. Int J Mol Sci 2017; 18 (10) Roles of Aryl Hydrocarbon Receptor in Aromatase-Dependent Cell Proliferation in Human Osteoblasts.
Application : ICC/IF
Reactivity : Human
Stevanato Filho PR et al. Pathol Oncol Res 2017; Estrogen Receptor β as a Prognostic Marker of Tumor Progression in Colorectal Cancer with Familial Adenomatous Polyposis and Sporadic Polyps.
Application : IHC-P
Reactivity : Human
Yuan B et al. Oncotarget 2016; 7 (27):42585-42597 Tyrosine phosphorylation regulates ERβ ubiquitination, protein turnover, and inhibition of breast cancer.
Application : WB
Reactivity : Human
Nuzzo MT et al. Mol Neurobiol 2016; (Epub) huntingtin polyq mutation impairs the 17β-*/neuroglobin pathway devoted to neuron survival.
Application : WB
Reactivity : Human
Makita H et al. J Oral Maxillofac Surg Med Pathol 2016; (Epub) A case of desmoplastic fibroma occurring at the mandible: Serial observations suggesting the successful effects of antihistamine agent and interaction of estrogen hormone.
Aiello A et al. Sci Rep 2016; 6:38414 MALAT1 and HOTAIR Long Non-Coding RNAs Play Opposite Role in Estrogen-Mediated Transcriptional Regulation in Prostate Cancer Cells.
Application : Dot
Reactivity : Human
McNamara KM et al. Breast Cancer Res Treat 2016; (Epub) The presence and impact of estrogen metabolism on the biology of triple-negative breast cancer.
Application : IHC-P
Reactivity : Human
Ladikou EE et al. Leuk Lymphoma 2016;:43112 The emerging role of estrogen in B cell malignancies.
Azmahani A et al. Hum Pathol 2016; (Epub) ERβ in Merkel cell carcinoma: its possible roles in pathogenesis.
Sareddy GR et al. Sci Rep 2016; 6:24185 Selective Estrogen Receptor β Agonist LY500307 as a Novel Therapeutic Agent for Glioblastoma.
Reactivity : Human
Bethea CL et al. Prog Neuropsychopharmacol Biol Psychiatry 2016; (Epub) Reproductive steroid receptors and actions in the locus coeruleus of male macaques: Part of an aggression circuit?
Application : IHC
Reactivity : Monkey
Ishida K et al. Pathol Int 2016; (Epub) Immunohistochemical analysis of steroidogenic enzymes in ovarian-type stroma of pancreatic mucinous cystic neoplasms: Comparative study of subepithelial stromal cells in intraductal papillary mucinous neoplasms of the pancreas.
Application : IHC
Reactivity : Human
Hamilton N et al. Biomed Res Int 2015; 2015:925703 biologic roles of estrogen receptor-β and *-like growth factor-2 in triple-negative breast cancer.
Application : IHC-P
Reactivity : Human
Mak P et al. Cell Rep 2015; 10 (12):1982-91 Prostate tumorigenesis induced by PTEN deletion involves estrogen receptor β repression.
Application : WB
Reactivity : Human
Maneix L et al. Proc Natl Acad Sci U S A 2015; 112 (16):5135-40 Estrogen receptor β exon 3-deleted mouse: The importance of non-ERE pathways in ERβ signaling.
Bethea CL et al. J Chem Neuroanat 2015; 66-67:19-27 Localization and regulation of reproductive steroid receptors in the raphe serotonin system of male macaques.
Application : IHC
Reactivity : Monkey
McCann SE et al. Nutr Cancer 2014; 66 (4):566-75 A pilot study comparing the effect of flaxseed, aromatase inhibitor, and the combination on breast tumor biomarkers.
Application : IHC-P
Reactivity : Human
Nikolos F et al. Mol Cancer Res 2014; 12 (6):843-54 ERβ regulates NSCLC phenotypes by controlling oncogenic RAS signaling.
Application : WB
Reactivity : Human
Rajapaksa G et al. Oncogene 2014; ERβ decreases breast cancer cell survival by regulating the IRE1/XBP-1 pathway.
Application : WB
Reactivity : Human
Curioni-Fontecedro A et al. Cytology & Histology 2014; (5) A Comprehensive Analysis of Markers for Neuroendocrine Tumors of the Lungs Demonstrates Estrogen Receptor Beta to be a Prognostic Markers in SCLC Male Patients
Application : IHC
Reactivity : Human
Yuan B et al. J Clin Invest 2014; A phosphotyrosine switch determines the antitumor activity of ERβ
Application : WB
Reactivity : Human
Taniuchi S et al. Mol Cell Endocrinol 2014; pii: S0303-7207 (14):00165-8 Tissue concentrations of estrogens and aromatase immunolocalization in interstitial pneumonia of human lung
Application : IHC-P
Reactivity : Human
Hsieh TH et al. Carcinogenesis 2014; Downregulation of SUN2, a novel tumor suppressor, mediates miR-221/222-induced malignancy in central nervous system embryonal tumors.
Application : IHC-P
Reactivity : Human
Ahn HY et al. Clin Endocrinol (Oxf) 2014; Loss of ERβ expression in papillary thyroid carcinoma is associated with recurrence in young female.
Application : IHC-P
Reactivity : Human
Velickovic K et al. J Clin Endocrinol Metab 2014; 99 (1):151-9 Expression and subcellular localization of estrogen receptors α and β in human fetal brown adipose tissue.
Application : WB
Khalaj AJ et al. Proc Natl Acad Sci U S A 2013; 110 (47):19125-30 Estrogen receptor (ER) β expression in oligodendrocytes is required for attenuation of clinical disease by an ERβ ligand.
Application : IHC
Reactivity : Mouse
Takagi K et al. Horm Cancer 2013; 4 (1):43111 Intratumoral estrogen concentration and expression of estrogen-induced genes in male breast carcinoma: comparison with female breast carcinoma.
Madeira M et al. BMC Cancer 2013; 13:425 estrogen receptor alpha/beta ratio and estrogen receptor beta as predictors of endocrine therapy responsiveness-a randomized neoadjuvant trial comparison between * and * for the treatment of postmenopausal breast cancer.
Application : IHC-P
Reactivity : Human
Hata S et al. Cancer Med 2013; 2 (3):305-15 Aromatase in human liver and its diseases.
Verma MK et al. J Transl Med 2013; 11:167 Intratumoral localization and activity of 17β-hydroxysteroid dehydrogenase type 1 in non-small cell lung cancer: a potent prognostic factor.
Application : IHC-P
Reactivity : Human
Thomas C et al. Breast Cancer Res 2012; 14 (6):R148 ERbeta1 represses basal breast cancer epithelial to mesenchymal transition by destabilizing EGFR.
Application : WB
Reactivity : Human
Sato R et al. Anticancer Res 2012; 32 (8):3069-75 Aromatase in colon carcinoma.
Samartzis N et al. Reprod Biol Endocrinol 2012; 10:30 Expression of the G protein-coupled estrogen receptor (GPER) in endometriosis: a tissue microarray study.
Application : IHC
Zuguchi M et al. Cancer Sci 2012; 103 (7):1348-55 Estrogen receptor α and β in esophageal squamous cell carcinoma.
Verma MK et al. Expert Opin Ther Targets 2012; 16 Suppl 1:S91-102 Cytoplasmic estrogen receptor β as a potential marker in human non-small cell lung carcinoma.
Navaratnam S et al. Horm Cancer 2012; 3 (3):93-100 Differential role of estrogen receptor beta in early versus metastatic non-small cell lung cancer.
Application : IHC
Reactivity : Human
Verma MK et al. Life Sci 2012; 91 (15-16):800-8 Co-expression of estrogen receptor beta and aromatase in Japanese lung cancer patients: gender-dependent clinical outcome.
Application : IHC-P
Reactivity : Human
Karlsson C et al. APMIS 2012; 120 (6):451-8 Oestrogen receptor β in NSCLC - prevalence, proliferative influence, prognostic impact and smoking.
Application : IHC
Reactivity : Human
Sase T et al. Int J Cancer 2012; 131 (10):2284-93 Runt-related transcription factor 2 in human colon carcinoma: a potent prognostic factor associated with estrogen receptor.
Choijamts B et al. Stem Cells 2011; 29 (10):1485-95 CD133+ cancer stem cell-like cells derived from uterine carcinosarcoma (malignant mixed M?llerian tumor).
Application : IHC
Honma N et al. Cancer Sci 2011; 102 (10):1848-54 Sex steroid hormones in pairs of tumor and serum from breast cancer patients and pathobiological role of androstene-3β, 17β-diol.
Application : WB
Reactivity : Human
Miki Y et al. Mol Cell Endocrinol 2011; 340 (2):168-74 Suppression of estrogen actions in human lung cancer.
Application : IHC
Reactivity : Human
Mehasseb MK et al. Fertil Steril 2011; 95 (7):2228-35, 2235.e1 Estrogen and progesterone receptor isoform distribution through the menstrual cycle in uteri with and without adenomyosis.
Application : IHC
Reactivity : Human
Vouk K et al. J Steroid Biochem Mol Biol 2011; 125 (43164):231-42 Novel estrogen-related genes and potential biomarkers of ovarian endometriosis identified by differential expression analysis.
Paruthiyil S et al. Breast Cancer Res Treat 2011; 129 (3):777-84 Estrogen receptor β causes a G2 cell cycle arrest by inhibiting CDK1 activity through the regulation of cyclin B1, GADD45A, and BTG2.
Application : ChIP assay
Reactivity : Human
Vivar OI et al. J Biol Chem 2010; 285 (29):22059-66 Estrogen receptor beta binds to and regulates three distinct classes of target genes.
Application : ChIP assay
Reactivity : Human
Matsuyama A et al. Pathol Int 2010; 60 (3):212-6 Vascular leiomyosarcoma: Clinicopathology and immunohistochemistry with special reference to a unique smooth muscle phenotype.
Mak P et al. Cancer Cell 2010; 17 (4):319-32 ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading.
Application : IHC
Reactivity : Human
Abe K et al. Hum Pathol 2010; 41 (2):190-8 Highly concordant coexpression of aromatase and estrogen receptor beta in non-small cell lung cancer.
Application : IHC
Reactivity : Human
Chakravarty D et al. Acta Histochem 2010; 112 (4):355-63 Steroid receptors, HER2/neu and Ki-67, in endometrioid type of endometrial carcinoma: Correlation with conventional histomorphological features of prognosis.
Application : IHC-P
Reactivity : Human
Huang GS et al. Am J Obstet Gynecol 2010; 203 (3):242.e1-5 Co-expression of GPR30 and ERbeta and their association with disease progression in uterine carcinosarcoma.
Application : IHC
Reactivity : Human
Vivar OI et al. Endocrinology 2010; 151 (4):1662-7 Selective activation of estrogen receptor-beta target genes by 3,3'-diindolylmethane.
Application : ChIP assay
Reactivity : Human
Jeong H et al. Basic and Applied Pathology. 2009; 2:118-24 Correlated expression of peroxisome proliferator-activated receptor γ with high histologic grade and basal type in invasive ductal carcinoma of the breast.
Application : IHC
Reactivity : Human
Miki Y et al. J Steroid Biochem Mol Biol 2009; 113 (43164):281-9 comparative effects of *, * and * on human osteoblasts in vitro: estrogen receptor dependent or independent pathways of *.
Application : ICC/IF
Reactivity : Human
Belcher SM et al. Endocrinology 2009; 150 (3):1112-21 Blockade of estrogen receptor signaling inhibits growth and migration of medulloblastoma.
Application : IHC-P
Reactivity : Human
Wong MH et al. J Clin Pathol 2009; 62 (9):789-93 Oestrogen receptor beta expression in pleomorphic adenomas of the parotid gland.
Application : IHC
Reactivity : Human
Raso MG et al. Clin Cancer Res 2009; 15 (17):5359-68 Immunohistochemical expression of estrogen and progesterone receptors identifies a subset of NSCLCs and correlates with EGFR mutation.
Application : IHC
Reactivity : Human
Maehle BO et al. APMIS 2009; 117 (9):644-50 Estrogen receptor beta--an independent prognostic marker in estrogen receptor alpha and progesterone receptor-positive breast cancer?
Application : IHC-P
Reactivity : Human
Paruthiyil S et al. PLoS One 2009; 4 (7):e6271 Drug and cell type-specific regulation of genes with different classes of estrogen receptor beta-selective agonists.
Application : WB
Reactivity : Human
Huang GS et al. Am J Obstet Gynecol 2009; 200 (4):457.e1-5 Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma.
Application : IHC-P
Reactivity : Human
Sato R et al. Cancer Res 2009; 69 (3):914-22 Steroid sulfatase and estrogen sulfotransferase in colon carcinoma: regulators of intratumoral estrogen concentrations and potent prognostic factors.
Application : IHC
Reactivity : Human
Urbanska K et al. J Cell Physiol 2009; 219 (2):392-401 Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma.
Application : ICC/IF
Reactivity : Human
Chakravarty D et al. Appl Immunohistochem Mol Morphol 2008; 16 (6):535-42 Estrogen receptor beta (ERbeta) in endometrial simple hyperplasia and endometrioid carcinoma.
Application : IHC
Reactivity : Human
Scariano JK et al. J Recept Signal Transduct Res 2008; 28 (3):285-93 Estrogen receptors alpha (ESR1) and beta (ESR2) are expressed in circulating human lymphocytes.
Application : WB
Reactivity : Human
Dohi O et al. Cancer Sci 2008; 99 (3):518-23 Sex steroid receptors expression and hormone-induced cell proliferation in human osteosarcoma.
Application : IHC
Reactivity : Human
Bukulmez O et al. Endocrinology 2008; 149 (3):1190-204 Inflammatory status influences aromatase and steroid receptor expression in endometriosis.
Application : IHC-P
Reactivity : Human
Setlur SR et al. J Natl Cancer Inst 2008; 100 (11):815-25 Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer.
Application : ChIP assay
Reactivity : Human
Ohata C et al. J Dermatol 2008; 35 (4):215-21 Expression of estrogen receptor beta in normal skin, melanocytic nevi and malignant melanomas.
Jones LP et al. Oncogene 2008; 27 (6):794-802 Activation of estrogen signaling pathways collaborates with loss of Brca1 to promote development of ERalpha-negative and ERalpha-positive mammary preneoplasia and cancer.
Cvoro A et al. Endocrinology 2007; 148 (2):538-47 Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract.
Application : ChIP assay
Reactivity : Human
Al-Dhaheri MH et al. Mol Endocrinol 2007; 21 (2):439-56 protein kinase a exhibits selective modulation of *-dependent transcription in breast cancer cells that is associated with decreased ligand binding, altered estrogen receptor alpha promoter interaction, and changes in receptor phosphorylation.
Application : WB
Reactivity : Human
Skliris GP et al. Breast Cancer Res Treat 2007; 104 (1):75-85 Estrogen receptor-beta regulates psoriasin (S100A7) in human breast cancer.
Application : IHC
Reactivity : Human
Caiazza F et al. Biochem Biophys Res Commun 2007; 359 (1):102-7 17beta-* induces erbeta up-regulation via p38/mapk activation in colon cancer cells.
Application : WB
Reactivity : Human
Gruvberger-Saal SK et al. Clin Cancer Res 2007; 13 (7):1987-94 estrogen receptor beta expression is associated with * response in eralpha-negative breast carcinoma.
Application : IHC-P
Reactivity : Human
Galluzzo P et al. Endocr Relat Cancer 2007; 14 (1):153-67 Role of ERbeta palmitoylation in the inhibition of human colon cancer cell proliferation.
Application : ICC/IF
Reactivity : Human
Dietrich W et al. J Soc Gynecol Investig 2006; 13 (7):512-7 Estrogen receptor-beta is the predominant estrogen receptor subtype in normal human synovia.
Application : IHC-P
Reactivity : Human
Skliris GP et al. Br J Cancer 2006; 95 (5):616-26 Expression of oestrogen receptor-beta in oestrogen receptor-alpha negative human breast tumours.
Application : IHC
Reactivity : Human
Savinov AY et al. Cancer Res 2006; 66 (5):2716-24 Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients.
Application : WB
Cvoro A et al. Mol Cell 2006; 21 (4):555-64 Distinct roles of unliganded and liganded estrogen receptors in transcriptional repression.
Application : ChIP assay
Reactivity : Human
Miki Y et al. Cancer Lett 2005; 220 (2):197-210 Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray.
Application : ICC/IF
Reactivity : Human
Jones LP et al. Oncogene 2005; 24 (22):3554-62 promotion of mammary cancer development by * in a mouse model of brca1-mutation-related breast cancer.
Application : IHC
Reactivity : Mouse
Poola I et al. Clin Cancer Res 2005; 11 (20):7579-85 Estrogen receptor alpha-negative breast cancer tissues express significant levels of estrogen-independent transcription factors, ERbeta1 and ERbeta5: potential molecular targets for chemoprevention.
Application : IHC
Reactivity : Human
Schwartz AG et al. Clin Cancer Res 2005; 11 (20):1965189 Nuclear estrogen receptor beta in lung cancer: expression and survival differences by sex.
Application : IHC
Reactivity : Human
Poola I et al. Endocrine 2005; 27 (3):227-38 Estrogen receptors beta4 and beta5 are full length functionally distinct ERbeta isoforms: cloning from human ovary and functional characterization.
Soliz J et al. Respir Physiol Neurobiol 2005; 149 (43103):111-22 Perinatal steroid exposure and respiratory control during early postnatal life.
Zheng FF et al. Mol Cell Biol 2005; 25 (18):8273-84 Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor.
Application : WB
Reactivity : Human
Ishibashi H et al. Cancer Res 2005; 65 (14):1662068 Progesterone receptor in non-small cell lung cancer--a potent prognostic factor and possible target for endocrine therapy.
Application : IHC
Reactivity : Human
Helguero LA et al. Oncogene 2005; 24 (44):6605-16 Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11.
Application : WB
Reactivity : Human
Hopp TA et al. Clin Cancer Res 2004; 10 (22):2041951 low levels of estrogen receptor beta protein predict resistance to * therapy in breast cancer.
Application : WB
Reactivity : Human
Koldzic-Zivanovic N et al. Mol Cell Endocrinol 2004; 226 (43102):33-42 Intracellular signaling involved in estrogen regulation of serotonin reuptake.
Balfe P et al. Eur J Surg Oncol 2004; 30 (5):469-74 Estrogen receptor alpha and beta profiling in human breast cancer.
Application : IHC
Reactivity : Human
Speirs V et al. Lancet Oncol 2004; 5 (3):174-81 Oestrogen receptor beta: what it means for patients with breast cancer.
Application : IHC
Reactivity : Human
Srilatha B et al. Urology 2004; 63 (2):382-6 Estrogen and phytoestrogen predispose to erectile dysfunction: do ER-alpha and ER-beta in the cavernosum play a role?
Paruthiyil S et al. Cancer Res 2004; 64 (1):423-8 Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest.
Application : WB
Reactivity : Human
Tee MK et al. Mol Biol Cell 2004; 15 (3):1262-72 * and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta.
Application : ChIP assay
Reactivity : Human
Kulakosky PC et al. Biotechniques 2003; 34 (2):334-8, 340-3 Maximizing production of estrogen receptor beta with the baculovirus expression system.
Tonetti DA et al. J Steroid Biochem Mol Biol 2003; 87 (1):47-55 Stable transfection of an estrogen receptor beta cDNA isoform into MDA-MB-231 breast cancer cells.
Application : ICC/IF
Reactivity : Human
Skliris GP et al. J Pathol 2003; 201 (2):213-20 Reduced expression of oestrogen receptor beta in invasive breast cancer and its re-expression using DNA methyl transferase inhibitors in a cell line model.
Application : IHC
Reactivity : Human
Li XQ et al. Pathol Int 2003; 53 (10):671-9 Expression of estrogen receptors alpha and beta in soft tissue sarcomas: Immunohistochemical and molecular analysis.
Application : IHC
Reactivity : Human
Omoto Y et al. Oncogene 2003; 22 (32):5011-20 Estrogen receptor (ER) beta1 and ERbetacx/beta2 inhibit ERalpha function differently in breast cancer cell line MCF7.
Application : ICC/IF
Reactivity : Human
Fuqua SA et al. Cancer Res 2003; 63 (10):195285 Estrogen receptor beta protein in human breast cancer: correlation with clinical tumor parameters.
Application : IHC
Reactivity : Human
Linja MJ et al. Prostate 2003; 55 (3):180-6 Expression of ERalpha and ERbeta in prostate cancer.
Application : IHC
Reactivity : Human
Saji S et al. Cancer Res 2002; 62 (17):4849-53 Expression of estrogen receptor (ER) (beta)cx protein in ER(alpha)-positive breast cancer: specific correlation with progesterone receptor.
Application : IHC
Reactivity : Human
Skliris GP et al. J Pathol 2002; 197 (2):155-62 Evaluation of seven oestrogen receptor beta antibodies for immunohistochemistry, western blotting, and flow cytometry in human breast tissue.
Application : FACS
Reactivity : Human
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