GeneTex
United States (US)

Factor XI antibody [N1N3]

GTX105974_WB_19011506_385.jpg
GTX105974_39932_IHC_19011506_164.jpg

Cat No. GTX105974

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:3000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

70 kDa. ( Note )

Positive Control

293T , Raji

Predict Reactivity

Rabbit, Dog(>80% identity)
PROPERTIES

Form

Liquid

Buffer

0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.)

Concentration

0.55mg/ml

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human Factor XI. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

FXI antibody, MGC141891 antibody, F11 antibody, plasma thromboplastin antecedent antibody, coagulation factor XI antibody, PTA antibody

Cellular Localization

Secreted

Background

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq]
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Database

DATA IMAGES
GTX105974_WB_19011506_385.jpg

GTX105974 WB Image

Sample(30 μg of whole cell lysate)
A:293T
7.5% SDS PAGE
GTX105974 diluted at 1:1000

GTX105974_39932_IHC_19011506_164.jpg

GTX105974 IHC-P Image

Immunohistochemical analysis of paraffin-embedded human breast cancer, using Factor XI(GTX105974) antibody at 1:250 dilution.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

SDS
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 319
$ 169