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Frizzled 7 antibody

Anti-Frizzled 7 antibody used in IHC (Paraffin sections) (IHC-P). GTX12996

Cat No. GTX12996

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

IHC-P, ELISA

Reactivity

Human, Mouse, Rat, Rabbit, Bovine, Dog, Hamster, Monkey, Bat
Package
25 μg ($289)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 15 μg/ml
ELISA Assay dependent

Note :

IHC-P
Heat induced antigen retrieval in pH 6.0 citrate buffer

Not tested in other applications.

Calculated MW

64 kDa. ( Note )

Predict Reactivity

Chicken, Elephant, Gibbon, Gorilla, Marmoset, Opossum, Panda, Xenopus, Platypus(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic 18 amino acid peptide from C-terminus of human FZD7 / Frizzled 7.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

frizzled class receptor 7 , FZD7 , FzE3

Cellular Localization

Cell membrane,Endosome membrane

Background

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Frizzled 7 antibody used in IHC (Paraffin sections) (IHC-P). GTX12996

GTX12996 IHC-P Image

IHC-P analysis of human heart tissue using GTX12996 Frizzled 7 antibody.
Antigen retrieval : Heat-induced antigen retrieval

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf