APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Dilution |
| 1 - 2 μg/mL |
| 2.5 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Mouse Brain Tissue Lysate(GTX27934)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Gle1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human Gle1.The immunogen is located within amino acids 540 - 590 of Gle1.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
GLE1 RNA export mediator , CAAHC , CAAHD , GLE1L , LCCS , LCCS1 , hGLE1
Cellular Localization
Nucleus,Cytoplasm
Background
This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX31366 IHC-P Image
IHC-P analysis of mouse brain tissue using GTX31366 GLE1 antibody.
Working concentration : 5 μg/ml
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GTX31366 IHC-P Image
IHC-P analysis of mouse brain tissue using GTX31366 GLE1 antibody.
Working concentration : 2.5 μg/ml
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GTX31366 WB Image
WB analysis of mouse brain tissue lysate using GTX31366 GLE1 antibody.
Working concentration : (A) 1 and (B) 2 μg/ml
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REFERENCE
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REVIEW
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