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United States (US)

Hepatitis A Virus antibody

Cat No. GTX30737

Host Goat
Clonality Polyclonal
Isotype IgG
Application ELISA
Reactivity Hepatitis A Virus
Package
500 μl ($319)
APPLICATION

Application Note

For ELISA: Use at a dilution of 1:1000. Optimal dilutions/concentrations should be determined by the end user.

Specificity/Sensitivity

All viral antigens. Negative cross reactivity against MRC5 cells
PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

5 mg/ml (Please refer to the vial label for the specific concentration.)

Immunogen

Purified virions of strain HM175

Purification

IgG fraction
Sodium sulfate precipitation and ion exchange chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Background

Hepatitis A Virus (HAV) is a 27nm nonenveloped, spherical, positive stranded RNA virus, classified within the genus hepatovirus of the picornavirus family and is among the smallest and structurally simplest of the RNA animal viruses. A single large polyprotein is expressed from a large open reading frame extending through most of the genomic RNA. This polyprotein is subsequently cleaved by a viral protease (3Cpro) to form three (possibly four) capsid proteins and several nonstructural proteins. HAV genomic replication occurs exclusively in the cytoplasm of the infected hepatocyte by a mechanism involving an RNA-dependent RNA polymerase. Though he clinical picture of viral (A) hepatitis is extremely variable - ranging from asymptotic infection without jaundice to a fulminating disease and death in a few days, Hepatitis A is usually a mild illness and does not lead to chronic or persistent hepatitis. HAV is transmitted by the orofecal route and is still endemic throughout much of the world, including the western world. HAV exists worldwide as a single serotype with a small degree of antigenetic variation. Present evidence suggests that immunity acquired naturally (or from an inactivated hepatitis A vaccine) will protect against all human HAV strains.

Research Area

REFERENCE
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REVIEW
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Package List Price ($)
$ 319