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Human FGFR1 protein, His tag (active)

Human FGFR1 protein, His tag (active). GTX01356-pro
Human FGFR1 protein, His tag (active). GTX01356-pro

Cat. No. GTX01356-pro

Application

Functional Assay

Species

Human
Package
100 μg ($349)

APPLICATION

Application Note

Measured by its ability to inhibit FGF-acidic (aFGF/FGF1) dependent proliferation of Balb/c 3T3 cells. The ED₅₀ for this effect is typically 0.1-0.6 μg/ml.

Observed MW

50-55 kDa.

PROPERTIES

Form

Lyophilized powder

Buffer

Batch dependent (please contact us for details)

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Avoid freeze-thaw cycles.

Region/Sequence

C-terminal poly His tagged; Met1-Glu285 of Human FGFR1 protein (NP_075594.1)

Expression System

HEK293 cells

Purity

> 98% by SDS-PAGE.

Endotoxin

< 1.0 EU/μg (determined by LAL method)

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

BFGFR,CD331,CEK,ECCL,FGFBR,FGFR-1,FLG,FLT-2,FLT2,HBGFR,HH2,HRTFDS,KAL2,N-SAM,OGD,bFGF-R-1

Background

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Human FGFR1 protein, His tag (active). GTX01356-pro

GTX01356-pro Functional Assay Image

The protein activity of GTX01356-pro Human FGFR1 protein was measured by its ability to inhibit FGF-acidic (aFGF / FGF1) dependent proliferation of Balb/c 3T3 cells.
ED₅₀ : 0.1-0.6 μg/ml in the presence of 0.2 ng/ml human FGF-acidic (aFGF / FGF1) protein

Human FGFR1 protein, His tag (active). GTX01356-pro

GTX01356-pro Image

SDS-PAGE of 5 μg GTX01356-pro Human FGFR1 protein, His tag (active).

REFERENCE

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REVIEW

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Package List Price ($)
$ 349