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Human IFNAR2 protein, human IgG1 Fc tag (active)

Human IFNAR2 protein, human IgG1 Fc tag (active). GTX01363-pro
Human IFNAR2 protein, human IgG1 Fc tag (active). GTX01363-pro

Cat No. GTX01363-pro

Application

Functional Assay

Species

Human
Package
100 μg ($329),
50 μg ($249)

APPLICATION

Application Note

Measured by its ability to inhibit rh IFNβ mediated protection of WISH cells infected with VSV (vesicular stomatitis virus) to viral lysis. The EC₅₀ for this effect is typically 0.2-1.2 μg/ml.
2. Measured by its binding ability in a functional ELISA. Immobilized Human Interferon alpha 2 protein (active) (GTX01426-pro) at 10 μg/ml (100 μL/well) can bind Human IFNAR2 protein (active) (GTX01363-pro). The EC₅₀ of Human IFNAR2 protein (active) (GTX01363-pro) is 60-200 ng/ml.

Observed MW

65-75 kDa.

PROPERTIES

Form

Lyophilized powder

Buffer

Batch dependent (please contact us for details)

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Avoid freeze-thaw cycles.

Region/Sequence

C-terminal human IgG1-Fc tagged; Met1-Lys243 of Human IFNAR2 protein (NP_997468.1)

Expression System

HEK293 cells

Purity

> 90% by SDS-PAGE.

Endotoxin

< 1.0 EU/μg (determined by LAL method)

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

IFN-R,IFN-alpha-REC,IFNABR,IFNARB,IMD45

Background

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Human IFNAR2 protein, human IgG1 Fc tag (active). GTX01363-pro

GTX01363-pro Image

SDS-PAGE of 5 μg GTX01363-pro Human IFNAR2 protein, human IgG1 Fc tag (active).

Human IFNAR2 protein, human IgG1 Fc tag (active). GTX01363-pro

GTX01363-pro Functional Assay Image

The protein binding activity was measured in a functional ELISA analysis of GTX01363-pro Human IFNAR2 protein which can bind immobilized GTX01426-pro Human Interferon alpha 2 protein.
Immobilized GTX01426-pro : 10 μg/ml (100 μl/well)
GTX01363-pro : 60-200 ng/ml

REFERENCE

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REVIEW

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Package List Price ($)
$ 329
$ 249