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Human IgM protein

Human IgM protein. GTX01553-pro

Cat No. GTX01553-pro

Species

Human
Package
1 mg ($199)

PROPERTIES

Form

Liquid

Buffer

0.1 M Tris Chloride, 0.5 M Sodium Chloride pH 8.0, 0.1% (w/v) sodium azide

Storage

Store as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Purification

Purified by delipidation, selective precipitation, and tandem molecular sieve chromatography followed by extensive dialysis.
From serum

Purity

Assayed by immunoelectrophoresis resulted in a single precipitin arc against anti-Human Serum and anti-Human IgM (μ chain specific). No reaction was observed against anti-Human IgG F(c). Some light chain cross-reactivity will occur with anti-Human IgG.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Background

Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).[supplied by OMIM, Aug 2010]

Database

  • Gene ID: 3507 IGHM

DATA IMAGES

Human IgM protein. GTX01553-pro

GTX01553-pro Image

SDS-PAGE of GTX01553-pro Human IgM protein.
Lane 1 : Reduced Human IgM
Lane 2 : 5 μl of Opal Pre-stained Marker
Lane 3 : Non-Reduced Human IgM
Loading : 1 μg per lane

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 199