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IGF1R alpha antibody [AMY10-105.8 (1H7)]

Cat. No. GTX20986

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 AMY10-105.8 (1H7)

Isotype

 IgG1

Application

 WB, Neutralizing/Inhibition

Reactivity

 Human
Package
50 μg ($399)
See all IGF1R products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
Neutralizing/Inhibition Assay dependent

Note :

Neutralizing/Inhibition
This antibody inhibits binding of IGF-1 and IGF-2. It also inhibits cell growth.
Not tested in other applications.

Calculated MW

155 kDa. ( Note )

Product Note

This antibody recognizes an epitope in the alpha subunits of IGF1R. Clone 1H7 is reported to partially block binding of IGF-I and IGF-II to IGF1 Receptor (Li et al.1993).

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Purified human placental IGF-1 receptors.

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD221 , IGF1R , IGFIR , IGFR , JTK13 , insulin like growth factor 1 receptor , IGF1R alpha , IGF1R beta , IGF1 Receptor alpha , IGF1 Receptor beta

Cellular Localization

Cell membrane

Background

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399