GeneTex
United States (US)

IL6 recombinant protein

Cat No. GTX65360

Application ELISA, Functional Assay, Apuri, Blocking
Reactivity Mouse
Species Mouse
APPLICATION

Application Note

The ED50(Effective Dosage 50%) as determined by the dose-dependent stimulation of the proliferation of the IL-6 dependent murine 7TD1 cells is <0.02 ng/ml, corresponding to a specific activity of >5x10^7 units/mg.

Calculated MW

21.7 kDa. ( Note )
PROPERTIES

Form

Lyophilized powder

Storage

Reconstitute in water to a concentration of 0.1-1.0 μg/μl. The solution can then be diluted into other aqueous buffers and stored at 4ºC for 1 week or –20ºC for future use.

Antigen Species

Mouse

Expression System

E. coli

Purification


Purity was assessed by SDS-PAGE (≥98%) and by HPLC (≥98%).

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

B cell differentiation factor (BCDF), HSF, Interleukin HP1, MGI2, BSF-2, MGI-2, B-cell hybridoma growth factor, IFN-b2, IL-6, Interleukin HP-1, IFNb2, BSF2, IL6, Bcell hybridoma growth factor, HPGF, IL 6, BSF 2, MGI 2, IFN b2, Interleukin HP 1, B cell hybridoma growth factor

Background

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R alpha and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant murine IL-6 is a 21.7 kDa protein containing 187 amino acid residues.

Research Area

Package List Price ($)
$ 249