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United States (US)

Insulin antibody (Ready-to-use)

Cat. No. GTX82959

Host

 Guinea pig

Clonality

 Polyclonal

Isotype

 IgG

Application

 IHC-P

Reactivity

 Human
Package
7 ml ($399)
See all Insulin products

APPLICATION

Application Note

For IHC-P: Supplied in ready to use form. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

12 kDa. ( Note )

Positive Control

Human pancreas

PROPERTIES

Form

Liquid

Buffer

Total immunoglobulin fraction in universal antibody dilution buffer.

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Human

Immunogen

Purified human insulin conjugated to carrier protein

Purification

Purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

insulin , IDDM , IDDM1 , IDDM2 , ILPR , IRDN , MODY10

Cellular Localization

Secreted

Background

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Database

Research Area

REFERENCE

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REVIEW

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Package List Price ($)
$ 399