APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 0.2-2.5 ug/ml |
| 2-10 ug/ml |
Not tested in other applications.
Calculated MW
Positive Control
HepG2 , human fetal liver
PROPERTIES
Form
Liquid
Buffer
PBS, 2% Sucrose
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.5-1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
A synthetic peptide corresponding to a C-terminal region of Human KCNN2.
Purification
Protein A purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
potassium calcium-activated channel subfamily N member 2 , KCa2.2 , SK2 , SKCA2 , SKCa 2 , hSK2
Cellular Localization
Membrane; Multi-pass membrane protein
Background
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Database
Research Area
DATA IMAGES
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GTX49068 IHC-P Image
IHC-P analysis of rat brain tissue using GTX49068 KCa2.2 antibody at 1:500.
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GTX49068 WB Image
WB analysis of human fetal liver tissue using GTX49068 KCa2.2 antibody at 1μg/ml.
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GTX49068 IHC-P Image
IHC-P analysis of Rhesus macaque spinal cord tissue using GTX49068 KCa2.2 antibody at 1:300.
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GTX49068 WB Image
WB analysis of HepG2 cells using GTX49068 KCa2.2 antibody at 1.25μg/ml.
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REFERENCE
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REVIEW
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