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Lamin A + C antibody [JoL5]

Cat. No. GTX25090

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 JoL5

Isotype

 IgG2

Application

 WB, ICC/IF

Reactivity

 Human, Mouse
Package
1 ml ($399)
See all Lamin A + C products

APPLICATION

Application Note

Recommended Starting Dilutions:
For WB: Use at 1/50
For ICC/IF: Use at 1:10
Optimal dilutions should be determined experimentally by the researcher.

Calculated MW

74 kDa. ( Note )

Product Note

Detects an un-phosphorylated form of lamin A/C and the epitope is mapped to the N-terminal head domain of both proteins. Works on human & mouse

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant bacterially expressed human lamin A

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

lamin A/C , CDCD1 , CDDC , CMD1A , CMT2B1 , EMD2 , FPL , FPLD , FPLD2 , HGPS , IDC , LDP1 , LFP , LGMD1B , LMN1 , LMNC , LMNL1 , MADA , PRO1

Cellular Localization

Nucleus , nucleoplasm

Background

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]

Database

Research Area

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399