Laminin alpha 3A antibody [BG5]

Cat. No. GTX17685
References 3
Cat. No.  GTX17685
Anti-Laminin alpha 3A antibody [BG5] used in (). GTX17685
GTX17685 Image

Protein structure of laminin-332s and binding sites of antibodies

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Anti-Laminin alpha 3A antibody [BG5] used in IHC (Paraffin sections) (IHC-P). GTX17685
GTX17685 IHC-P Image

IHC-P analysis of various tissue samples using GTX17685 Laminin alpha 3A antibody [BG5].
Figure A : Normal skin tissue (paraffin slice)
Figure B : Normal mammary gland (paraffin slice)
Figure C : Normal lung tissue (paraffin slice)

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Anti-Laminin alpha 3A antibody [BG5] used in IHC (Paraffin sections) (IHC-P). GTX17685
GTX17685 IHC-P Image

IHC-P analysis of skin cancer tissue using GTX17685 Laminin alpha 3A antibody [BG5].

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Anti-Laminin alpha 3A antibody [BG5] used in Western Blot (WB). GTX17685
GTX17685 WB Image

WB analysis of recombinant human intact laminin 3A32 protein (containing alpha 3A, Beta 3, gamma 2 chains) using GTX17685 Laminin alpha 3A antibody [BG5].
Dilution : 1:10000
Reduced condition : 7% gel
Non-reduced condition : 5% gel

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Anti-Laminin alpha 3A antibody [BG5] used in ELISA (ELISA). GTX17685
GTX17685 ELISA Image

ELISA anaiysis of five recombinant human laminins using GTX17684 Laminin alpha 3B antibody [F7] and GTX17685 Laminin alpha 3A antibody [BG5].

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Anti-Laminin alpha 3A antibody [BG5] used in (). GTX17685
Anti-Laminin alpha 3A antibody [BG5] used in IHC (Paraffin sections) (IHC-P). GTX17685
Anti-Laminin alpha 3A antibody [BG5] used in IHC (Paraffin sections) (IHC-P). GTX17685
Anti-Laminin alpha 3A antibody [BG5] used in Western Blot (WB). GTX17685
Anti-Laminin alpha 3A antibody [BG5] used in ELISA (ELISA). GTX17685
  • Host
    Mouse
  • Clonality
    Monoclonal
  • Clone Name
    BG5
  • Isotype
    IgG2a
  • Applications
    WB IHC-P IHC-Fr IP ELISA Purification
  • Reactivity
    Human
Summary
Laminins, which consist of three subunits called alpha, beta and gamma chains, are major cell-adhesive components of extracellular matrix, especially basement membranes (BMs). The laminin family is constituted of over 15 isoforms, and each member is expressed in a tissue-specific manner and plays a differential role in each tissue. In the case of laminin alpha 3 chain, there are two splicing variants, the truncated form alpha 3A and the full-length alpha 3B.. Laminin-3A32 (Lm3A32) , formerly called laminin-5 or -5A, is composed of alpha 3A, Beta 3 and gamma 2 chains and distributed in the skin, esophagus, lung, breast and other epithelial tissues. This antibody highly detects laiminin-3A32 in the basement membranes of normal epithelial tissues and of relatively benign or differentiated carcinomas. It may also detect laminin-3A11. As its sister clone F7 is specific for alpha 3B chain, the combination of BG5 and F7 is an important tool to investigate the difference of the full- length and truncated alpha 3 laminins. These antibodies, together with the anti-gamma 2 antibody P2H capable of detecting invasive cancers, are powerful tools in pathological analyses of human cancers.
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