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MUC1 antibody

Anti-MUC1 antibody used in IHC (Paraffin sections) (IHC-P). GTX14690
Anti-MUC1 antibody used in IHC (Paraffin sections) (IHC-P). GTX14690

Cat No. GTX14690

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 IHC-P, IP, ELISA

Reactivity

 Human, Monkey, Baboon
Package
100 μg ($399)
See all MUC1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P Assay dependent
IP 1:200
ELISA 1:10000
Not tested in other applications.

Calculated MW

122 kDa. ( Note )

Product Note

The antibody will detect deglycosylated MUCIN1 protein.

PROPERTIES

Form

Liquid

Buffer

Tris/Glycine pH7.4-7.9, 30% Glycerol, 0.5% BSA

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.65 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on MUCIN1 protein.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

mucin 1, cell surface associated , ADMCKD , ADMCKD1 , CA 15-3 , CD227 , EMA , H23AG , KL-6 , MAM6 , MCD , MCKD , MCKD1 , MUC-1 , MUC-1/SEC , MUC-1/X , MUC1/ZD , PEM , PEMT , PUM

Cellular Localization

Apical cell membrane , Cytoplasm , Nucleus

Background

This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

Database

Research Area

DATA IMAGES

Anti-MUC1 antibody used in IHC (Paraffin sections) (IHC-P). GTX14690

GTX14690 IHC-P Image

IHC-P analysis of baboon lung tissue using GTX14690 MUC1 antibody.
Dilution : 1:100

Anti-MUC1 antibody used in IHC (Paraffin sections) (IHC-P). GTX14690

GTX14690 IHC-P Image

IHC-P analysis of baboon lung tissue using GTX14690 MUC1 antibody.
Dilution : 1:100

REFERENCE

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REVIEW

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Package List Price ($)
$ 399