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Mu Opioid receptor antibody

Anti-Mu Opioid receptor antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX10275
Anti-Mu Opioid receptor antibody used in IHC (Frozen sections) (IHC-Fr). GTX10275

Cat No. GTX10275

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF, IHC-Fr
Reactivity Human, Mouse, Rat, Bovine, Guinea pig, Pig, Monkey, Primate
Package
50 μl ($319)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:1,000
ICC/IF 1:100 - 1:2,000
IHC-Fr 1:100 - 1:2,000
Not tested in other applications.

Calculated MW

44 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

Preservative: 0.05% Sodium Azide; Constituents: Whole Serum

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Rat

Immunogen

Synthetic peptide: NHQLENLEAETAPLP, corresponding to C terminal amino acids 384-398 of Rat Mu Opioid Receptor.

Purification

Whole antiserum

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Opioid Receptor, Mu 1,Mora,Oprm,Oprrm1,Oprm1

Cellular Localization

Integral membrane protein.

Background

The powerful effects of opiate are mediated through the opioid receptors located on the plasma membrane of neurons and other peripheral cells. There are at least 3 types of opioid receptors, mu, kappa, and delta, each with a distinct pharmacologic profile. The mu opioid receptor is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone. Three types of opioid receptors have been cloned mu, delta, and kappa. Opioid receptors are seven transmembrane G-protein coupled receptors. They share a high degree of homology and are most divergent at the N and C-termini. Activation of mu opioid receptors leads to a decrease in neuronal excitability. Expression of Mu Opioid Receptor has been reported mostly in brain and spinal cord.

Database

Research Area

DATA IMAGES
Anti-Mu Opioid receptor antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX10275

GTX10275 ICC/IF Image

Double immunofluorescence labeling showing the presence of a subpopulation of spinal lamina II neurons that contained both µ opioid receptor (green) and TRPV1 (red) immunoreactivity in a vehicle (A)- and a RTX (B)-treated rats. Co-localization of the µ opioid receptor and TRPV1 immunoreactivity is indicated in yellow when 2 images are digitally merged. All images are single confocal optical sections. Scale bar: 20 µm

Anti-Mu Opioid receptor antibody used in IHC (Frozen sections) (IHC-Fr). GTX10275

GTX10275 IHC-Fr Image

MOR staining of Rat DRG (dilution: 1:100) incubation at 4 °C overnight. Secondary antibody is anti-Rabbit Rhodamine Red (dilution:1:200) incubation at room temperature for 1 hour.

REFERENCE
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Package List Price ($)
$ 319