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NUP98 antibody [3B8-D7-H10]

Anti-NUP98 antibody [3B8-D7-H10] used in Immunoprecipitation (IP). GTX49240
Anti-NUP98 antibody [3B8-D7-H10] used in Western Blot (WB). GTX49240

Cat No. GTX49240

Host

Mouse

Clonality

Monoclonal

Clone Name

3B8-D7-H10

Isotype

IgG1

Application

WB, IP

Reactivity

Human
Package
100 μg ($379)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

198 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

0.1M Tris-Glycine (pH7.4), 150mM NaCl, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Purified recombinant human NUP98 protein fragments expressed in E.coli.

Purification

Affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

nucleoporin 98 , ADIR2 , NUP196 , NUP96

Cellular Localization

nucleoplasm

Background

Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]

Database

DATA IMAGES

Anti-NUP98 antibody [3B8-D7-H10] used in Immunoprecipitation (IP). GTX49240

GTX49240 IP Image

IP analysis of HeLa lysates using control IgG and NUP98 antibody. The precipitates were detected by the same NUP98 antibody.

Anti-NUP98 antibody [3B8-D7-H10] used in Western Blot (WB). GTX49240

GTX49240 WB Image

WB analysis of HeLa, Jurkat and MCF7 lysates using NUP98 antibody at a dilution of 1:1,000.

REFERENCE

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REVIEW

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SDS
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 379