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NUP98 antibody [3B8-D7-H10]

Anti-NUP98 antibody [3B8-D7-H10] used in Immunoprecipitation (IP). GTX49240
Anti-NUP98 antibody [3B8-D7-H10] used in Western Blot (WB). GTX49240

Cat No. GTX49240

Host

Mouse

Clonality

Monoclonal

Clone Name

3B8-D7-H10

Isotype

IgG1

Application

WB, IP

Reactivity

Human
Package
100 μg ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

98 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50% glycerol

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Purified recombinant human NUP98 protein fragments expressed in E.coli.

Purification

Affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Nucleoporin 98 , Adir2 , Nup196 , Nup96 , Nup98

Cellular Localization

Nucleus > nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side.

Background

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

Database

DATA IMAGES

Anti-NUP98 antibody [3B8-D7-H10] used in Immunoprecipitation (IP). GTX49240

GTX49240 IP Image

IP analysis of HeLa lysates using control IgG and NUP98 antibody. The precipitates were detected by the same NUP98 antibody.

Anti-NUP98 antibody [3B8-D7-H10] used in Western Blot (WB). GTX49240

GTX49240 WB Image

WB analysis of HeLa, Jurkat and MCF7 lysates using NUP98 antibody at a dilution of 1:1,000.

REFERENCE

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REVIEW

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SDS
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 319