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PALB2 antibody

Anti-PALB2 antibody used in Western Blot (WB). GTX85263

Cat. No. GTX85263

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($409)
See all PALB2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 - 2 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

131 kDa. ( Note )

Positive Control

SK-N-SH Cell Lysate(GTX23956)

Product Note

At least four isoforms of PALB2 are known to exist; this antibody will detect all four isoforms.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

PALB2 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human PALB2.The immunogen is located within amino acids 940 - 990 of PALB2.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

partner and localizer of BRCA2 , FANCN , PNCA3

Cellular Localization

Nucleus

Background

The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.

Database

Research Area

DATA IMAGES

Anti-PALB2 antibody used in Western Blot (WB). GTX85263

GTX85263 WB Image

WB analysis of SK-N-SH cell lysate using GTX85263 PALB2 antibody.
Working concentration : 1 μg/ml

REFERENCE

Application Reference

So A et al. Nucleic Acids Res 2022; (Epub) RAD51 protects against nonconservative DNA double-strand break repair through a nonenzymatic function.
Application : WB
Reactivity : Human
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 409