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PMS2 antibody

Anti-PMS2 antibody used in Western Blot (WB). GTX66694
Anti-PMS2 antibody used in IHC (Paraffin sections) (IHC-P). GTX66694
Anti-PMS2 antibody used in IHC (Paraffin sections) (IHC-P). GTX66694
Anti-PMS2 antibody used in Western Blot (WB). GTX66694
Anti-PMS2 antibody used in IHC (Paraffin sections) (IHC-P). GTX66694

Cat No. GTX66694

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human, Mouse, Rat
Package
100 μl ($339)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
IHC-P 1:50-1:200
Not tested in other applications.

Calculated MW

96 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS pH7.2, 0.05% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml

Antigen Species

Human

Immunogen

Synthetic peptide, corresponding to amino acids 450-500 of Human PMS2.

Purification

Purified by antigen-affinity chromatography
From serum

Purity

> 95% (by SDS-PAGE)

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

PMS1 homolog 2, mismatch repair system component , HNPCC4 , MLH4 , PMS2CL , PMSL2

Cellular Localization

Nucleus

Background

The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. [provided by RefSeq, Apr 2016]

Database

Research Area

DATA IMAGES
Anti-PMS2 antibody used in Western Blot (WB). GTX66694

GTX66694 WB Image

WB analysis of various samples using GTX66694 PMS2 antibody.
Lane1 : A549 whole cell lysate
Lane2 : Raw264.7 whole cell lysate
Lane3 : H9C2 whole cell lysate
Dilution : 1:500

Anti-PMS2 antibody used in IHC (Paraffin sections) (IHC-P). GTX66694

GTX66694 IHC-P Image

IHC-P analysis of human breast carcinoma tissue using GTX66694 PMS2 antibody.
Left : Primary antibody
Right : Negative control
Dilution : 1:50

Anti-PMS2 antibody used in IHC (Paraffin sections) (IHC-P). GTX66694

GTX66694 IHC-P Image

IHC-P analysis of human kidney carcinoma tissue using GTX66694 PMS2 antibody.
Left : Primary antibody
Right : Negative control
Dilution : 1:50

Anti-PMS2 antibody used in Western Blot (WB). GTX66694

GTX66694 WB Image

WB analysis of various samples using GTX66694 PMS2 antibody.
Lane1 : A549 whole cell lysate
Lane2 : Raw264.7 whole cell lysate
Lane3 : H9C2 whole cell lysate
Lane4 : Hela whole cell lysate
Dilution : 1:500

Anti-PMS2 antibody used in IHC (Paraffin sections) (IHC-P). GTX66694

GTX66694 IHC-P Image

IHC-P analysis of human colon carcinoma tissue using GTX66694 PMS2 antibody.
Left : Primary antibody
Right : Negative control
Dilution : 1:50

REFERENCE
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Package List Price ($)
$ 339