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PSTPIP1 antibody

Anti-PSTPIP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX33443
Anti-PSTPIP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX33443
Anti-PSTPIP1 antibody used in Western Blot (WB). GTX33443

Cat. No. GTX33443

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all PSTPIP1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

48 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 157-416 of human PSTPIP1 (NP_003969.2).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

proline-serine-threonine phosphatase interacting protein 1 , CD2BP1 , CD2BP1L , CD2BP1S , H-PIP , PAPAS , PSTPIP

Cellular Localization

Cytoplasm,Cell membrane,Cytoplasm, cytoskeleton

Background

This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response. [provided by RefSeq, Mar 2016]

Database

Research Area

DATA IMAGES

Anti-PSTPIP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX33443

GTX33443 IHC-P Image

IHC-P analysis of human stomach tissue using GTX33443 PSTPIP1 antibody.
Dilution : 1:100

Anti-PSTPIP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX33443

GTX33443 IHC-P Image

IHC-P analysis of mouse kidney tissue using GTX33443 PSTPIP1 antibody.
Dilution : 1:100

Anti-PSTPIP1 antibody used in Western Blot (WB). GTX33443

GTX33443 WB Image

WB analysis of various sample lysates using GTX33443 PSTPIP1 antibody.
Dilution : 1:1000
Loading : 25μg per lane

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399