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ROR alpha antibody [N2N3]

KO/KD
Anti-ROR alpha antibody [N2N3] used in Western Blot (WB). GTX100029
Anti-ROR alpha antibody [N2N3] used in Western Blot (WB). GTX100029
Anti-ROR alpha antibody [N2N3] used in Western Blot (WB). GTX100029

Cat. No. GTX100029

Reference 4

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399),
25 μl ($169)
See all ROR alpha products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
Not tested in other applications.

Calculated MW

63 kDa. ( Note )

Positive Control

Mouse brain , HeLa , NIH-3T3

Predict Reactivity

Bovine, Xenopus tropicalis(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 20% Glycerol

Preservative

0.01% Thimerosal

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human ROR alpha. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_1081007

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

RAR related orphan receptor A , IDDECA , NR1F1 , ROR1 , ROR2 , ROR3 , RZR-ALPHA , RZRA

Background

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-ROR alpha antibody [N2N3] used in Western Blot (WB). GTX100029

GTX100029 WB Image

Sample (30 ug of whole cell lysate)
A: Hela
7.5% SDS PAGE
GTX100029 diluted at 1:1000

Anti-ROR alpha antibody [N2N3] used in Western Blot (WB). GTX100029

GTX100029 WB Image

Sample (30 ug of whole cell lysate)

A:NIH-3T3
7.5% SDS PAGE

GTX100029 diluted at 1:5000

Anti-ROR alpha antibody [N2N3] used in Western Blot (WB). GTX100029

GTX100029 WB Image

Sample (50 ug of whole cell lysate)
A: Mouse brain
7.5% SDS PAGE
GTX100029 diluted at 1:1000

REFERENCE

Application Reference

Beak JY et al. J Biol Chem 2021; 297 (6) : 101358 The nuclear receptor RORα preserves cardiomyocyte mitochondrial function by regulating caveolin-3-mediated mitophagy.
Application : WB
Reactivity : Rat
Luo J et al. Nat Commun 2019; 10 (1) : 2571 LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2/STAT3 signaling.
Beak JY et al. Am J Physiol Heart Circ Physiol 2019; 316 (1) : H186-H200 The nuclear receptor RORα protects against angiotensin II-induced cardiac hypertrophy and heart failure.
Application : WB
Reactivity : Mouse
Bro?yna AA et al. Oncotarget 2016; RORα and RORγ expression inversely correlates with human melanoma progression.
Application : WB
Reactivity : Human
Submit a Reference

REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Thimerosal.pdf
Document
Unmodified.pdf
Package List Price ($)
$ 399
$ 169