SMN1 antibody [2F1]

Cat. No. GTX60451

Host	Mouse
Clonality	Monoclonal
Clone Name	2F1
Isotype	IgG1
Application	WB, IHC-P, FACS, ELISA
Reactivity	Human, Monkey
Package	100 μl ($409)

See all SMN1 products

Datasheet
Document

View product citations for antibody GTX60451 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	1/500 - 1/2000
IHC-P	1/200 - 1/1000
FACS	1/200 - 1/400
ELISA	1/10000

Not tested in other applications.

Calculated MW

32 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Ascites

Preservative

0.03% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Purified recombinant fragment of human SMN1 expressed in E. Coli.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

survival of motor neuron 1, telomeric , BCD541 , GEMIN1 , SMA , SMA1 , SMA2 , SMA3 , SMA4 , SMA@ , SMN , SMNT , T-BCD541 , TDRD16A

Cellular Localization

Cytoplasm

Background

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve t

Database

Gene ID: 6606 SMN1
UniProt: Q16637 SMN1

Research Area

DATA IMAGES

GTX60451 ELISA Image

ELISA analysis of antigen using GTX60451 SMN1 antibody [2F1].
Red : Control antigen 100ng
Purple : Antigen 10ng
Green : Antigen 50ng
Blue : Antigen 100ng

GTX60451 IHC-P Image

IHC-P analysis of testis tissue (left) and lung cancer tissue (right) using GTX60451 SMN1 antibody [2F1].

GTX60451 FACS Image

FACS analysis of HepG2 cells using GTX60451 SMN1 antibody [2F1].
Green : SMN1
Purple : negative control

GTX60451 WB Image

WB analysis of HepG2 (1), HeLa (2), K562 (3), Jurkat (4), SKBR-3 (5), A431 (6) and Cos7 (7) cell lysate using GTX60451 SMN1 antibody [2F1].

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf

Package

List Price ($)

100 μl

$ 409

Qty