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SMN1 antibody

Anti-SMN1 antibody used in Western Blot (WB). GTX101047
Anti-SMN1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX101047

Cat No. GTX101047

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF
Reactivity Human
100 μl ($319),
25 μl ($169)

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500-1:3000
ICC/IF 1:100-1:1000
Not tested in other applications.

Calculated MW

32 kDa. ( Note )

Positive Control

293T , A431 , HeLa , HepG2

Predict Reactivity

Mouse, Rat, Pig, Rhesus Monkey(>80% identity)




1XPBS, 40% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.


Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.


1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species



Recombinant protein encompassing a sequence within the center region of human SMN1. The exact sequence is proprietary.


Purified by antigen-affinity chromatography.




For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.


survival of motor neuron 1, telomeric,BCD541,GEMIN1,SMA,SMA1,SMA2,SMA3,SMA4,SMA@,SMN,SMNT,T-BCD541,TDRD16A


This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Two transcript variants encoding distinct isoforms have been described. [provided by RefSeq]


Research Area

Anti-SMN1 antibody used in Western Blot (WB). GTX101047

GTX101047 WB Image

Various whole cell extracts (30 µg) were separated by 12% SDS-PAGE, and the membrane was blotted with SMN1 antibody (GTX101047) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-SMN1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX101047

GTX101047 ICC/IF Image

Immunofluorescence analysis of methanol-fixed HeLa, using SMN1(GTX101047) antibody at 1:200 dilution.

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Package List Price ($)
$ 319
$ 169