GeneTex

  • Country / Location Selection

United States (US)

T Cell Factor 3 + 4 antibody [6F12-3]

Cat. No. GTX12065

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 6F12-3

Isotype

 IgG1

Application

 WB, IHC-P

Reactivity

 Human, Mouse
Package
25 μg ($399)
See all TCF3 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1-4 μg/ml
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

62 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

0.1M Tris-Glycine pH7.4, 0.15M Sodium Chloride, 30% Glycerol

Preservative

0.08% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

~0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

His-tagged fusion protein corresponding to amino acids 31-331 of human TCF.

Purification

Purified immunoglobulin

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

transcription factor 7 like 1 (T cell specific, HMG box) , Tcf-3 , Tcf3 , bHLHb21

Cellular Localization

Nucleus

Background

T-cell factor 3 and 4 (TCF3 and TCF4) are transcription factors of the High Mobility Group of DNA binding proteins. They are members of a family of four proteins referred to as LEF/TCF transcription factors (LEF1, TCF1, TCF3 and TCF4). These factors play crucial roles in WNT/Wingless signaling, a signal transduction cascade that directs cell differentiation. Aberrant activation of the WNT/Wingless pathway is also a root cause in the genesis of certain cancers such as colon cancer, melanoma and breast cancer. TCF4 generates transcriptionally active complexes with beta catenin in colon carcinoma cells. TCF3 appears to be expressed independently of TCF4 in the hair follicles, stomach epithelium, and keratinocytes of the skin.

Database

Research Area

REFERENCE

There are currently no references for T Cell Factor 3 + 4 antibody [6F12-3] (GTX12065). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for T Cell Factor 3 + 4 antibody [6F12-3] (GTX12065). Be the first to share your experience with this product.
Submit a Review
SDS
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399