GeneTex
United States (US)

TERT antibody [2C4]

GTX30410_1397_WB_18121410_276.jpg
GTX30410_324_IHC-P_18121410_607.jpg
GTX30410_323_IHC-P_18121410_162.jpg

Cat No. GTX30410

Host Mouse
Clonality Monoclonal
Clone Name 2C4
Isotype IgM
Application WB, ICC/IF, IHC-P, IP, WB-Ag
Reactivity Human, Mouse
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500
ICC/IF Assay dependent
IHC-P 1:50
IP 1:10 - 1:500
WB-Ag Assay dependent
Not tested in other applications.

Calculated MW

127 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

Ascites, 0.02% Sodium Azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Full-length recombinant human Telomerase reverse transcriptase from insect cells. [UniProt# O14746].

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Telomerase Reverse Transcriptase,Cmm9,Dkca2,Dkcb4,Est2,Pfbmft1,Tcs1,Tp2,Trt,Hest2,Htrt,Tert

Cellular Localization

Nucleus,Telomere

Background

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq]

Database

Research Area

DATA IMAGES
GTX30410_1397_WB_18121410_276.jpg

GTX30410 WB Image

WB analysis of MJ90 cell lysate using GTX30410 TERT antibody [2C4].
Dilution : 1:500

GTX30410_324_IHC-P_18121410_607.jpg

GTX30410 IHC-P Image

IHC-P analysis of human pancreas tissue using GTX30410 TERT antibody [2C4].

GTX30410_323_IHC-P_18121410_162.jpg

GTX30410 IHC-P Image

IHC-P analysis of human pancreas carcinoma tissue using GTX30410 TERT antibody [2C4].

REFERENCE
Package List Price ($)
$ 369