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TERT antibody [2C4]

Anti-TERT antibody [2C4] used in IHC (Paraffin sections) (IHC-P). GTX30410
Anti-TERT antibody [2C4] used in Western Blot (WB). GTX30410
Anti-TERT antibody [2C4] used in IHC (Paraffin sections) (IHC-P). GTX30410

Cat No. GTX30410

Host

Mouse

Clonality

Monoclonal

Clone Name

2C4

Isotype

IgM

Application

WB, ICC/IF, IHC-P, IP

Reactivity

Human, Mouse
Package
100 μl ($389)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500
ICC/IF Assay dependent
IHC-P 1:50
IP 1:10 - 1:500
Not tested in other applications.

Calculated MW

127 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Ascites, 0.02% Sodium Azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Full-length recombinant human Telomerase reverse transcriptase from insect cells. [UniProt# O14746].

Purification

Unpurified

Conjugation

Unconjugated

RRID

AB_370403

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

telomerase reverse transcriptase , CMM9 , DKCA2 , DKCB4 , EST2 , PFBMFT1 , TCS1 , TP2 , TRT , hEST2 , hTRT

Cellular Localization

nucleoplasm,Nucleus,Cytoplasm,Nucleolus

Background

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-TERT antibody [2C4] used in IHC (Paraffin sections) (IHC-P). GTX30410

GTX30410 IHC-P Image

IHC-P analysis of human pancreas carcinoma tissue using GTX30410 TERT antibody [2C4].

Anti-TERT antibody [2C4] used in Western Blot (WB). GTX30410

GTX30410 WB Image

WB analysis of MJ90 cell lysate using GTX30410 TERT antibody [2C4].
Dilution : 1:500

Anti-TERT antibody [2C4] used in IHC (Paraffin sections) (IHC-P). GTX30410

GTX30410 IHC-P Image

IHC-P analysis of human pancreas tissue using GTX30410 TERT antibody [2C4].

REFERENCE

REVIEW

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SDS
Sodium Azide.pdf