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United States (US)

TFF1 antibody

Cat No. GTX28762

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 IHC-P, IHC-Fr, ELISA

Reactivity

 Human
Package
250 μl ($289)
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APPLICATION

Application Note

Immunohistochemistry 1:25-1:50. This antibody can be used on both frozen and formalin-fixed, paraffin-embedded tissue sections. Prolonged fixation in buffered formalin can destroy the epitope. This antibody may be used at a dilution of 1:25-1:50. For paraffin sections, incubation of primary antibody for one hour at 37º is recommended. The optimum conditions should be determined by the individual laboratory.

Calculated MW

9 kDa. ( Note )

Positive Control

About 70% of breast carcinomas show partial staining of tumor cells.

Product Note

This antibody is specific to pS2 protein, also known as pNR-2.

PROPERTIES

Form

Liquid

Buffer

Serum

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Human

Immunogen

Synthetic peptide representing a highly antigenic site near the C-terminus of the pS2 protein.

Purification

Whole antiserum

Conjugation

Unconjugated

RRID

AB_368414

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

trefoil factor 1 , BCEI , D21S21 , HP1.A , HPS2 , pNR-2 , pS2

Cellular Localization

Secreted

Background

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

Application Reference

Arumugam T et al. Pancreas 2011; 40 (6) : 815-22 Trefoil factor 1 stimulates both pancreatic cancer and stellate cells and increases metastasis.
Application : ELISA
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SDS
Sodium Azide.pdf
Package List Price ($)
$ 289