Form
Liquid
Buffer
100 μl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50% glycerol.
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Antigen Species
Rat
Immunogen
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser19 conjugated to KLH
Purification
Affinity Purified
Conjugation
Unconjugated
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Synonyms
ADHD7, FLJ37295, MGC138871, TPH2, tryptophan hydroxylase2, tryptophan hydroxylase 2, MGC138872, NTPH, TPH2 (phospho S19), TPH2 (phospho Ser19), TPH2 (pS19), TPH2 (pSer19), TPH2 phospho S19, TPH2 phospho Ser19, Phospho TPH2 (S19), Phospho TPH2 (Ser19), Phospho TPH2 (pS19), Phospho TPH2 (pSer19)
Background
Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin (5-HT) and might be related to the pathogenesis of major depression (MD). Two isoforms are known, TPH1 and TPH2. . TPH1 is phosphorylated by cAMP-dependent protein kinase A . Recently, it has been shown that expression of the TPH1 gene is increased in lungs and pulmonary endothelial cells from patients with idiopathic pulmonary arterial hypertension. Results indicate that TPH1 and peripheral serotonin play an essential role in the development of hypoxia-induced elevations in pulmonary pressures and hypoxia-induced pulmonary vascular remodeling. In addition, the results suggest that, in mice, serotonin has differential effects on the pulmonary vasculature and right ventricular hypertrophy.
Database
Research Area
