PBS, 0.02% sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Immunogen Sequence: GI # 26051243, sequence 248-260 Synthetic peptide sequence of tumor necrosis factor, α-induced protein 6.
Purified by affinity chromatography
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TNF alpha induced protein 6 , TSG-6 , TSG6
Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis. The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain. and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I). and thus enhance the serine protease inhibitory activity of I alpha I. which is important in the protease network associated with inflammation. The expression of this gene can be induced by tumor necrosis factor alpha and interleukin-1. The expression can also be induced by mechanical stimuli in vascular smooth muscle cells. and is found to be correlated with proteoglycan synthesis and aggregation.