Application Note
For IHC-P: Use at an assay dependent dilution. For WB: Use at a concentration of 1-2 μg/ml. Optimal dilutions/concentrations should be determined by the researcher.
Calculated MW
Specificity/Sensitivity
GTX12357 stains the human neurofibrillary tangles, neuropil threads and neuritic plaques associated with Alzheimer's disease. The antibody also stains astrocytes and ribosomes. Tau-2 may be used with formalin-fixed paraffin-embedded sections of human brain tissue.
Form
Liquid
Buffer
Phosphate-buffered saline, pH 7.4, and 150 mM containing 0.09% sodium azide and 1% BSA
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration
0.1 mg/ml (Please refer to the vial label for the specific concentration.)
Immunogen
Recombinant full length protein
Purification
Protein A/G purified
Conjugation
Biotin
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Synonyms
microtubule associated protein tau , DDPAC , FTDP-17 , MAPTL , MSTD , MTBT1 , MTBT2 , PPND , PPP1R103 , TAU
Cellular Localization
Cytoplasm, cytosol , Cell membrane , Cytoplasm, cytoskeleton , Cytoplasm , Cell projection, dendrite
Background
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
Database
Research Area