*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
Detects Thymidylate Synthase by immunochemistry in proliferating cell cultures and tissues but does not stain non-proliferating cells.Normal colon mucosa shows weak staining. However, some colorectal cancer specimens show very strong staining.
0.02 M Potassium phosphate, 0.15 M sodium chloride, pH 7.2, containing 0.01% sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Batch dependent (Please refer to the vial label for the specific concentration.)
Recombinant human Thymidylate synthase (36 kDa) produced in E.coli .
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
thymidylate synthetase , HST422 , TMS , TS
Nucleus,Cytoplasm,Mitochondrion,Mitochondrion matrix,Mitochondrion inner membrane
Because inhibition of Thymidylate Synthase (TS) prevents DNA synthesis and cell proliferation, the enzyme is an important target for cancer chemotherapeutic drugs, specifically the fluoropyrimidine group of antineoplastic drugs used to treat solid tumors.