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Thyroglobulin antibody [2H11]

Anti-Thyroglobulin antibody [2H11] used in IHC (Paraffin sections) (IHC-P). GTX35115

Cat No. GTX35115

Host

Mouse

Clonality

Monoclonal

Clone Name

2H11

Isotype

IgG1

Application

IHC-P, FACS

Reactivity

Human, Mouse, Rat
Package
100 μg ($339)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 0.1-0.2μg/ml|30 min at RT
FACS 1-2μg/10⁶ cells

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95ºC followed by cooling at RT for 20 minutes.

Not tested in other applications.

Calculated MW

305 kDa. ( Note )

Specificity/Sensitivity

MAb 2H11 reacts with a partially defined epitope of human thyroglobulin. This epitope is different form the epitope recognized by MAb 6E1.

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA, 0.05% sodium azide (Please contact us for PBS only format)

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml

Antigen Species

Human

Immunogen

Human thyroid follicular cells

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

AITD3,TG,TGN,thyroglobulin,Thyroglobulin

Cellular Localization

Secreted

Background

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]

Database

Research Area

DATA IMAGES

Anti-Thyroglobulin antibody [2H11] used in IHC (Paraffin sections) (IHC-P). GTX35115

GTX35115 IHC-P Image

IHC-P analysis of human thyroid tissue using GTX35115 Thyroglobulin antibody [2H11].

REFERENCE

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REVIEW

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Package List Price ($)
$ 339