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Titin antibody

Anti-Titin antibody used in IHC (Paraffin sections) (IHC-P). GTX34284
Anti-Titin antibody used in IHC (Paraffin sections) (IHC-P). GTX34284
Anti-Titin antibody used in IHC (Paraffin sections) (IHC-P). GTX34284
Anti-Titin antibody used in IHC (Paraffin sections) (IHC-P). GTX34284

Cat No. GTX34284

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

IHC-P

Reactivity

Human
Package
100 μl ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 1:50-1:300
Not tested in other applications.

Calculated MW

3816 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS pH 7.4, 0.02% sodium azide, 50% Glycerol

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide from human TTN protein at 161-210 aa.

Purification

Purified by antigen-affinity chromatography
From serum

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CMD1G,CMH9,CMPD4,EOMFC,HMERF,LGMD2J,MYLK5,TMD,TTN,titin,Titin

Cellular Localization

Cytoplasm,Nucleus

Background

This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012]

Database

Research Area

DATA IMAGES

Anti-Titin antibody used in IHC (Paraffin sections) (IHC-P). GTX34284

GTX34284 IHC-P Image

IHC-P analysis of human heart tissue using GTX34284 Titin antibody.
Dilution : 1:200

Anti-Titin antibody used in IHC (Paraffin sections) (IHC-P). GTX34284

GTX34284 IHC-P Image

IHC-P analysis of human skeletal muscle tissue using GTX34284 Titin antibody.
Dilution : 1:200

Anti-Titin antibody used in IHC (Paraffin sections) (IHC-P). GTX34284

GTX34284 IHC-P Image

IHC-P analysis of human skeletal muscle tissue using GTX34284 Titin antibody.
Dilution : 1:200

Anti-Titin antibody used in IHC (Paraffin sections) (IHC-P). GTX34284

GTX34284 IHC-P Image

IHC-P analysis of human heart tissue using GTX34284 Titin antibody.
Dilution : 1:200

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 319