GeneTex
United States (US)

Titin antibody

Anti-Titin antibody used in IHC (Paraffin sections) (IHC-P). GTX34284
Anti-Titin antibody used in IHC (Paraffin sections) (IHC-P). GTX34284
Anti-Titin antibody used in IHC (Paraffin sections) (IHC-P). GTX34284
Anti-Titin antibody used in IHC (Paraffin sections) (IHC-P). GTX34284

Cat No. GTX34284

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application IHC-P, ELISA
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

3816 kDa. ( Note )

Specificity/Sensitivity

The antibody detects endogenous TTN.
PROPERTIES

Form

Liquid

Buffer

PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Synthetic peptide from human protein at AA range: 161-210.

Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Titin,Cmd1G,Cmh9,Cmpd4,Eomfc,Hmerf,Lgmd2J,Mylk5,Salmy,Tmd,Ttn

Background

This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variant

Database

Research Area

DATA IMAGES
Anti-Titin antibody used in IHC (Paraffin sections) (IHC-P). GTX34284

GTX34284 IHC-P Image

Immunohistochemical analysis of paraffin-embedded human-heart, antibody was diluted at 1:200.

Anti-Titin antibody used in IHC (Paraffin sections) (IHC-P). GTX34284

GTX34284 IHC-P Image

Immunohistochemical analysis of paraffin-embedded human-skeletal-muscle, antibody was diluted at 1:200.

Anti-Titin antibody used in IHC (Paraffin sections) (IHC-P). GTX34284

GTX34284 IHC-P Image

Immunohistochemical analysis of paraffin-embedded human-heart, antibody was diluted at 1:200.

Anti-Titin antibody used in IHC (Paraffin sections) (IHC-P). GTX34284

GTX34284 IHC-P Image

Immunohistochemical analysis of paraffin-embedded human-skeletal-muscle, antibody was diluted at 1:200.

Package List Price ($)
$ 319