Form
Liquid
Buffer
PBS pH 7.4, 0.09 % sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4º C.
Concentration
Batch dependent(Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Human skTnI
Purification
Protein A purified
Conjugation
Unconjugated
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Synonyms
AMCD2B, DA2B, FSSV, TNNI2, fsTnI, troponin I2, fast skeletal type, Troponin I fast skeletal muscle, fast skeletal muscle Troponin I
Background
This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
Database
